David B. Horton, Ph.D.

Affiliations: 
Pharmaceutical Sciences University of Kentucky, Lexington, KY 
Area:
Drug and alcohol abuse
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"David Horton"
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Linda P. Dwoskin grad student 2012 University of Kentucky
 (Discovery of GZ-793A, a novel VMAT2 inhibitor and potential pharmacotherapy for methamphetamine abuse.)
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Publications

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Nickell JR, Siripurapu KB, Horton DB, et al. (2016) GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2. European Journal of Pharmacology. 795: 143-149
Beckmann JS, Meyer AC, Pivavarchyk M, et al. (2015) r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement. Neurochemical Research
Horton DB, Nickell JR, Zheng G, et al. (2013) GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine. Journal of Neurochemistry. 127: 177-86
Horton DB, Potter DM, Mead AN. (2013) A translational pharmacology approach to understanding the predictive value of abuse potential assessments. Behavioural Pharmacology. 24: 410-36
Narayanaswami V, Somkuwar SS, Horton DB, et al. (2013) Angiotensin AT1 and AT2 receptor antagonists modulate nicotine-evoked [³H]dopamine and [³H]norepinephrine release. Biochemical Pharmacology. 86: 656-65
Zheng G, Horton DB, Penthala NR, et al. (2013) Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse. Medchemcomm. 4: 564-568
Horton DB, Siripurapu KB, Zheng G, et al. (2011) Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of Pharmacology and Experimental Therapeutics. 339: 286-97
Meyer AC, Horton DB, Neugebauer NM, et al. (2011) Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration. Neuropharmacology. 61: 849-56
Horton DB, Siripurapu KB, Norrholm SD, et al. (2011) meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of Pharmacology and Experimental Therapeutics. 336: 940-51
Crooks PA, Zheng G, Vartak AP, et al. (2011) Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse. Current Topics in Medicinal Chemistry. 11: 1103-27
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