Jacob M. Basak, Ph.D.
Affiliations: | Biology and Biomedical Sciences (Molecular Cell Biology) | Washington University, Saint Louis, St. Louis, MO |
Area:
Alzheimer's, amyloidGoogle:
"Jacob Basak"Mean distance: 16.52 (cluster 31)
Parents
Sign in to add mentor| David M. Holtzman | grad student | 2014 | Washington University | |
| (Modulating Amyloid beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism.) | ||||
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Publications
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| Basak JM, Falk M, Mitchell DN, et al. (2023) Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X231159597 |
| Basak JM, Ferreiro A, Cohen LS, et al. (2021) Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease. Neurobiology of Disease. 105292 |
| Han BH, Zhou ML, Johnson AW, et al. (2015) Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice. Proceedings of the National Academy of Sciences of the United States of America. 112: E881-90 |
| Kim J, Yoon H, Basak J, et al. (2014) Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms. Molecules and Cells. 37: 767-76 |
| Kim J, Eltorai AE, Jiang H, et al. (2012) Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis. The Journal of Experimental Medicine. 209: 2149-56 |
| Wildsmith KR, Basak JM, Patterson BW, et al. (2012) In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. Plos One. 7: e38013 |
| Basak JM, Kim J, Pyatkivskyy Y, et al. (2012) Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling. Molecular Neurodegeneration. 7: 14 |
| Basak JM, Verghese PB, Yoon H, et al. (2012) Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes. The Journal of Biological Chemistry. 287: 13959-71 |
| Wildsmith KR, Basak JM, Patterson BW, et al. (2012) Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS Plos One. 7 |
| Kim J, Jiang H, Park S, et al. (2011) Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 18007-12 |