Jacob M. Basak, Ph.D.

Affiliations: 
Biology and Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Alzheimer's, amyloid
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"Jacob Basak"
Mean distance: 16.52 (cluster 31)
 

Parents

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David M. Holtzman grad student 2014 Washington University
 (Modulating Amyloid beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism.)
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Publications

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Han BH, Zhou ML, Johnson AW, et al. (2015) Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice. Proceedings of the National Academy of Sciences of the United States of America. 112: E881-90
Kim J, Yoon H, Basak J, et al. (2014) Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms. Molecules and Cells. 37: 767-76
Kim J, Eltorai AE, Jiang H, et al. (2012) Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis. The Journal of Experimental Medicine. 209: 2149-56
Wildsmith KR, Basak JM, Patterson BW, et al. (2012) In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. Plos One. 7: e38013
Basak JM, Kim J, Pyatkivskyy Y, et al. (2012) Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling. Molecular Neurodegeneration. 7: 14
Basak JM, Verghese PB, Yoon H, et al. (2012) Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes. The Journal of Biological Chemistry. 287: 13959-71
Kim J, Jiang H, Park S, et al. (2011) Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 18007-12
Basak JM, Holtzman DM. (2011) APP-based transgenic models: The PDAPP model Neuromethods. 48: 371-385
Basak JM, Kim J. (2010) Differential effects of ApoE isoforms on dendritic spines in vivo: linking an Alzheimer's disease risk factor with synaptic alterations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4526-7
Kim J, Castellano JM, Jiang H, et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 64: 632-44
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