☰

Anne L. Brunkan, Ph.D.

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
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http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=72
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"Anne Brunkan"
Mean distance: 18.86 (cluster 28)
 
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Parents

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Alison M. Goate grad student 2004 Washington University
 (Characterization of domains important for stabilization and maturation of the Alzheimer's disease protein presenilin -1, and their impact on presenilinase and gamma-secretase activity.)

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Publications

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Brunkan AL, Martinez M, Wang J, et al. (2005) Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity. Journal of Neurochemistry. 94: 1315-28
Brunkan AL, Martinez M, Walker ES, et al. (2005) Presenilin endoproteolysis is an intramolecular cleavage. Molecular and Cellular Neurosciences. 29: 65-73
Brunkan AL, Goate AM. (2005) Presenilin function and gamma-secretase activity. Journal of Neurochemistry. 93: 769-92
Brunkan AL, Martinez M, Wang J, et al. (2005) A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities. Journal of Neurochemistry. 92: 1158-69
Walker ES, Martinez M, Brunkan AL, et al. (2005) Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios. Journal of Neurochemistry. 92: 294-301
Wang J, Brunkan AL, Hecimovic S, et al. (2004) Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes. Neurobiology of Disease. 15: 654-66
Walker ES, Martinez M, Brunkan A, et al. (2004) P4-309 Presenilin 2 familial Alzheimer's disease mutation decrease Aβ and CTFγ while differentially affecting NICD production Neurobiology of Aging. 25: S563
Brunkan AL, Martinez M, Goate AM. (2004) P4-283 Endoproteolysis of presenilin-1 is an intramolecular autocatalytic event Neurobiology of Aging. 25: S555-S556
Schroeter EH, Ilagan MX, Brunkan AL, et al. (2003) A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80
Zhou Y, Zhang W, Easton R, et al. (2002) Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG. Neurobiology of Disease. 9: 126-38
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