Ray Kelleher

Affiliations: 
Harvard Medical School, Boston, MA, United States 
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"Ray Kelleher"
Mean distance: 13.77 (cluster 6)
 
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Parents

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Alexander Rich research assistant MIT (Chemistry Tree)
Roger D. Kornberg grad student Stanford Medical School (Chemistry Tree)
Susumu Tonegawa post-doc MIT
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Publications

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Xia D, Watanabe H, Wu B, et al. (2015) Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. Neuron. 85: 967-81
Grishchuk Y, Sri S, Rudinskiy N, et al. (2014) Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathologica Communications. 2: 133
Heilig EA, Gutti U, Tai T, et al. (2013) Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11606-17
Kelleher RJ, Geigenmüller U, Hovhannisyan H, et al. (2012) High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism. Plos One. 7: e35003
Watanabe H, Xia D, Kanekiyo T, et al. (2012) Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5085-96
Anguera MC, Ma W, Clift D, et al. (2011) Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. Plos Genetics. 7: e1002248
Kelleher RJ, Shen J. (2010) Genetics. Gamma-secretase and human disease. Science (New York, N.Y.). 330: 1055-6
Heilig EA, Xia W, Shen J, et al. (2010) A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. The Journal of Biological Chemistry. 285: 22350-9
Tong Y, Yamaguchi H, Giaime E, et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 9879-84
Wines-Samuelson M, Schulte EC, Smith MJ, et al. (2010) Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. Plos One. 5: e10195
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