Joseph A. Fraietta, Ph.D.

Affiliations: 
2012 Drexel University College of Medicine, Philadelphia, PA, United States 
Area:
HIV, CD8 T cell
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"Joseph Fraietta"
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Parents

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Peter D. Katsikis grad student 2012 Drexel Medical School
 (Targeting Inflammation for the Prevention of Human Immunodeficiency Virus (HIV) Transmission and Disease Progression.)
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Publications

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Myers RM, Devine KJ, Li Y, et al. (2024) Reinfusion of CD19 CAR T Cells for Relapse Prevention and Treatment in Children with Acute Lymphoblastic Leukemia. Blood Advances
Ghilardi G, Fraietta JA, Gerson JN, et al. (2024) T-cell Lymphoma and Secondary Primary Malignancy Risk After Commercial CAR T-cell Therapy. Nature Medicine
Mackall C, Doan A, Mueller K, et al. (2023) FOXO1 is a master regulator of CAR T memory programming. Research Square
Agarwal S, Aznar MA, Rech AJ, et al. (2023) Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells. Immunity. 56: 2388-2407.e9
Noll JH, Levine BL, June CH, et al. (2023) Beyond youth: Understanding CAR T cell fitness in the context of immunological aging. Seminars in Immunology. 70: 101840
Collins SM, Alexander KA, Lundh S, et al. (2023) TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells. Science Advances. 9: eadh2605
Jung IY, Noguera-Ortega E, Bartoszek R, et al. (2023) Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors. Cell Reports. Medicine. 101053
Jung IY, Bartoszek RL, Rech AJ, et al. (2023) Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction. Cancer Discovery
Collins MA, Jung IY, Zhao Z, et al. (2022) Enhanced Costimulatory Signaling Improves CAR T-cell Effector Responses in CLL. Cancer Research Communications. 2: 1089-1103
Melenhorst JJ, Chen GM, Wang M, et al. (2022) Author Correction: Decade-long leukaemia remissions with persistence of CD4 CAR T cells. Nature
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