Michael A. Chattergoon, Ph.D.

Affiliations: 
2003 University of Pennsylvania, Philadelphia, PA, United States 
Area:
DNA vaccine, HIV
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"Michael Chattergoon"
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Parents

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David B. Weiner grad student 2003 Penn
 (Engineered apoptosis as an immune adjuvant: The use of DR5 as an immune adjuvant.)
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Publications

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Chattergoon MA, Latanich R, Quinn J, et al. (2014) HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon. Plos Pathogens. 10: e1004082
Serti E, Werner JM, Chattergoon M, et al. (2014) Monocytes activate natural killer cells via inflammasome-induced interleukin 18 in response to hepatitis C virus replication. Gastroenterology. 147: 209-220.e3
Osburn WO, Levine JS, Chattergoon MA, et al. (2013) Anti-inflammatory cytokines, pro-fibrogenic chemokines and persistence of acute HCV infection. Journal of Viral Hepatitis. 20: 404-13
Chattergoon MA, Levine JS, Latanich R, et al. (2011) High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection. The Journal of Infectious Diseases. 204: 1730-40
Muthumani K, Shedlock DJ, Choo DK, et al. (2011) HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 2932-43
Kutzler MA, Kraynyak KA, Nagle SJ, et al. (2010) Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo. Gene Therapy. 17: 72-82
Chattergoon MA, Muthumani K, Tamura Y, et al. (2008) DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 419-26
Ramanathan MP, Chambers JA, Pankhong P, et al. (2006) Host cell killing by the West Nile Virus NS2B-NS3 proteolytic complex: NS3 alone is sufficient to recruit caspase-8-based apoptotic pathway. Virology. 345: 56-72
Muthumani K, Choo AY, Hwang DS, et al. (2005) HIV-1 Viral protein-r (Vpr) protects against lethal superantigen challenge while maintaining homeostatic T cell levels in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 910-21
Kutzler MA, Robinson TM, Chattergoon MA, et al. (2005) Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help. Journal of Immunology (Baltimore, Md. : 1950). 175: 112-23
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