Ana Garcia-Osta

Affiliations: 
CIMA, Pamplona, Pamplona, Navarra, Spain 
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"Ana Garcia-Osta"
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Publications

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Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, et al. (2019) Multitarget Approach for the Treatment of Alzheimer`s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) covering diverse selectivity profiles. Acs Chemical Neuroscience
Cuadrado-Tejedor M, Pérez-González M, García-Muñoz C, et al. (2019) Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease. Frontiers in Aging Neuroscience. 11: 149
Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, et al. (2018) Discovery of in-vivo chemical probes for treating Alzheimer´s disease: Dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitors. Acs Chemical Neuroscience
Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, et al. (2018) Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry. 150: 506-524
Sánchez-Arias JA, Rabal O, Cuadrado-Tejedor M, et al. (2016) Impact of scaffold exploration on novel dual-acting histone deacetylases (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for the treatment of Alzheimer's Disease. Acs Chemical Neuroscience
Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, et al. (2016) Design, synthesis, and biological evaluation of first-in-class dual acting histone deacetylases (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for the treatment of Alzheimer's disease. Journal of Medicinal Chemistry
Cuadrado-Tejedor M, Garcia-Barroso C, Sánchez-Arias JA, et al. (2016) A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5, and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Cuadrado-Tejedor M, García-Osta A. (2016) Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer's Disease Phenotype in Mouse Models. Methods in Molecular Biology (Clifton, N.J.). 1303: 241-6
García-Osta A, Cuadrado-Tejedor M. (2016) Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models. Methods in Molecular Biology (Clifton, N.J.). 1303: 117-23
Peixoto CA, Nunes AK, Garcia-Osta A. (2015) Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation. 2015: 940207
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