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Ohara Augusto, Ph.D.

Affiliations: 
1977- Departamento de Bioquímica University of São Paulo, São Paulo, São Paulo, Brazil 
Area:
Chemistry and Biochemistry of Free Radicals, Applications of Electronic Paramagnetic Resonance (EPR) in Biomedicine, Biological Oxidations, Redox Equilibrium in cells and organisms, Nitric Oxide and derived oxidants
Website:
http://www.iq.usp.br/oaugusto/indexing.html
Google:
"Ohara Augusto"
Bio:

She entered the Chemistry undergraduate program of the Chemical Institute of the University of São Paulo, IQ/USP, in 1967. She was however, only an average student during the course. Times were troubled, the course structure was very rigid and there were financial difficulties. These factors led her to teach Chemistry at the high school level during the night period (1969/1971) instead of researching in the Institute's laboratories. Once she earned her Bachelor's degree, she still believed her calling was to do scientific research, so she chose graduate school. She knew very little about the work being developed at the Institute, but was lucky to be a personal friend of Prof. Francisco G. Nóbrega, who advised her look for Prof. Giuseppe Cilento.
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Mean distance: 8.27
 
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Parents

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Giuseppe Cilento grad student 1972-1975 USP
 (Ph.D. student)
Lester Packer post-doc 1979-1980 UC Berkeley
Paul R. Ortiz de Montellano post-doc 1980-1982 UCSF
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Publications

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Dantas LS, Viviani LG, Inague A, et al. (2020) Lipid aldehyde hydrophobicity affects apo-SOD1 modification and aggregation. Free Radical Biology & Medicine. 156: 157-167
Truzzi DR, Alves SV, Netto LES, et al. (2020) The Peroxidatic Thiol of Peroxiredoxin 1 is Nitrosated by Nitrosoglutathione but Coordinates to the Dinitrosyl Iron Complex of Glutathione. Antioxidants (Basel, Switzerland). 9
Gonçalves LCP, Massari J, Licciardi S, et al. (2020) Singlet oxygen generation by the reaction of acrolein with peroxynitrite via a 2-hydroxyvinyl radical intermediate. Free Radical Biology & Medicine. 152: 83-90
Truzzi DR, Augusto O, Iretskii AV, et al. (2019) Dynamics of Dinitrosyl Iron Complex (DNIC) Formation with Low Molecular Weight Thiols. Inorganic Chemistry
Truzzi DR, Coelho FR, Paviani V, et al. (2019) The bicarbonate/carbon dioxide pair increases hydrogen peroxide-mediated hyperoxidation of human peroxiredoxin 1. The Journal of Biological Chemistry
Truzzi DR, Augusto O, Ford PC. (2019) Thiyl radicals are co-products of dinitrosyl iron complex (DNIC) formation. Chemical Communications (Cambridge, England)
Augusto O, Goldstein S, Hurst JK, et al. (2019) Carbon Dioxide-catalyzed peroxynitrite reactivity - The Resilience of the radical mechanism after two decades of research. Free Radical Biology & Medicine
Damasceno FC, Condeles AL, Lopes AKB, et al. (2018) The labile iron pool attenuates peroxynitrite-dependent damage and can no longer be considered solely a pro-oxidative cellular iron source. The Journal of Biological Chemistry
Truzzi DR, Coelho FR, Paviani V, et al. (2018) Bicarbonate increases peroxiredoxin 1 susceptibility to hyperoxidation Free Radical Biology and Medicine. 120: S37
Augusto O. (2018) CO 2 toxicity: Role for redox reactions? Free Radical Biology and Medicine. 120: S23
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