Norbert Perrimon

Affiliations: 
1986- Genetics Harvard University, Cambridge, MA, United States 
Website:
https://perrimon.med.harvard.edu/
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"Norbert Perrimon"
Bio:

Dr. Perrimon has 30 years of experience in the fields of developmental genetics, signal transduction and genomics. By developing, improving, and applying a number of genetic techniques (germline clones, FLP/FRT, Gal4/UAS, etc.), his group identified many key components of the Receptor Tyrosine Kinases, JAK/STAT, Wnt, Hedgehog and Notch signaling pathways. In recent years, his group established high-throughput genome-wide RNAi screens to systematically interrogate the entire Drosophila genome in various cell-based assays. In 2003 he created the Drosophila RNAi Screening Center at Harvard Medical School to make this technology available to the community. In addition, in 2008, he initiated the Transgenic RNAi Project to generate transgenic RNAi lines for the community using optimized shRNA vectors that his lab developed. Currently, his laboratory is applying large-scale RNAi and proteomic methods to obtain a global understanding to the structure of a number of signaling pathways and their crosstalks. In addition, he is studying the roles of signaling pathways in homeostasis and tissue remodeling in Drosophila muscles and gut stem cells. Dr. Perrimon has trained more than 80 students and postdoctoral fellows, most of whom currently hold academic positions.
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Mean distance: 15.51 (cluster 11)
 
SNBCP
Cross-listing: FlyTree - Computational Biology Tree

Parents

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Madeleine Gans grad student 1983 University of Paris VI (FlyTree)
 (Thesis: "Analyse Clonale de Mutations en Lignee Germinale chez la Drosophile")
Anthony P. Mahowald post-doc 1983-1986 Chicago (FlyTree)

Children

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Kimberly Sayer Kerr research assistant 1998-2005 Harvard Medical School
Ilia Droujinine grad student Harvard Medical School
Young Kwon grad student Harvard Medical School
John A. Klingensmith grad student 1986-1993 Harvard
Yohanns Bellaïche grad student 1994-1998 Harvard (FlyTree)
Adam Amiel Friedman grad student 2007 Harvard (FlyTree)
William Tyler Gibson grad student 2012 Harvard (FlyTree)
Jimmy Kuang-Hsien Hu grad student 2012 Harvard (FlyTree)
Erika Bach post-doc NYU School of Medicine (FlyTree)
Chris Bakal post-doc Harvard Medical School
David Bilder post-doc (FlyTree)
Andrea H. Brand post-doc Harvard
Katja Brueckner post-doc
Nirmalya Chatterjee post-doc
Sara Cherry post-doc (FlyTree)
Daniel F. Eberl post-doc
Arpan C. Ghosh post-doc Harvard Medical School (FlyTree)
Udo Häcker post-doc Harvard Medical School (FlyTree)
Douglas A. Harrison post-doc (FlyTree)
Li He post-doc Harvard Medical School (FlyTree)
Xinhua Lin post-doc
Chryssoula Pitsouli post-doc Harvard Medical School (FlyTree)
Esther Seigfried post-doc (FlyTree)
Eric Spana post-doc (FlyTree)
Change Tan post-doc University of Missouri (FlyTree)
Stephane Vincent post-doc ENS Lyon (FlyTree)
Raghuvir R. Viswanatha post-doc Harvard Medical School (Cell Biology Tree)
Frederik Wirtz-Peitz post-doc Harvard (FlyTree)
Jonathan D. Zirin post-doc
Ben Ewen-Campen post-doc 2014- Harvard Medical School (FlyTree)
Afroditi Petsakou post-doc 2015- Harvard Medical School (Chemistry Tree)
Sudhir Gopal Tattikota post-doc 2016- Harvard Medical School
Lucy Liu post-doc 2017- Harvard Medical School
Rajendhran Rajakumar post-doc 2017- Harvard Medical School
Joshua Shing Shun Li post-doc 2019- Harvard Medical School
Jeff Axelrod post-doc 1993-1998 Harvard Medical School (FlyTree)
Willis X Li post-doc 1995-2000 Harvard Medical School (FlyTree)
Beth E. Stronach post-doc 1998-2002 genetics department, harvard medical school (FlyTree)
Frieder Schöck post-doc 1999-2003 Harvard Medical School (FlyTree)
Amy Kiger post-doc 2000-2004 Harvard (FlyTree)
Craig A. Micchelli post-doc 2000-2006 Harvard (Cell Biology Tree)
Matt Gibson post-doc 2001-2006 Harvard (FlyTree)
Michele Markstein post-doc 2004-2012 Harvard Medical School (FlyTree)
Marla B. Tipping post-doc 2011-2013 Harvard (FlyTree)
Phillip Karpowicz post-doc 2008-2014 Harvard Medical School (FlyTree)
Edward K. Owusu-Ansah post-doc 2009-2014 Harvard Medical School
Akhila Rajan post-doc 2009-2016 Harvard Medical School (FlyTree)
Dong Yan post-doc 2010-2016 (FlyTree)
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Publications

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Cho S, Lee G, Pickering BF, et al. (2021) mTORC1 promotes cell growth via mA-dependent mRNA degradation. Molecular Cell
Mohr SE, Tattikota SG, Xu J, et al. (2021) Methods and tools for spatial mapping of single-cell RNAseq clusters in Drosophila. Genetics
Tang HW, Weng JH, Lee WX, et al. (2021) mTORC1-chaperonin CCT signaling regulates mA RNA methylation to suppress autophagy. Proceedings of the National Academy of Sciences of the United States of America. 118
Hung RJ, Li JSS, Liu Y, et al. (2021) Defining cell types and lineage in the Drosophila midgut using single cell transcriptomics. Current Opinion in Insect Science
Parkhitko AA, Singh A, Hsieh S, et al. (2021) Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. Plos Genetics. 17: e1009354
Ghosh AC, Tattikota SG, Liu Y, et al. (2021) Correction: PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity. Elife. 10
Wang W, Li J, Tan J, et al. (2021) Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nature Communications. 12: 476
Bosch JA, Birchak G, Perrimon N. (2021) Precise genome engineering in using prime editing. Proceedings of the National Academy of Sciences of the United States of America. 118
Parkhitko AA, Ramesh D, Wang L, et al. (2020) Downregulation of the tyrosine degradation pathway extends lifespan. Elife. 9
Ghosh AC, Tattikota SG, Liu Y, et al. (2020) PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity. Elife. 9
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