Rebecca J. Howard, Ph.D.

2007 Chemistry and Chemical Biology University of California, San Francisco, San Francisco, CA 
Channel Physiology
"Rebecca Howard"
Mean distance: 15.68 (cluster 6)


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Dan Minor grad student 2007 UCSF
 (Structure and assembly properties of a conserved C-terminal domain in Kv7 channels.)
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Heusser SA, Yoluk Ö, Klement G, et al. (2016) Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel. Journal of Neurochemistry
Horani S, Stater EP, Corringer PJ, et al. (2015) Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors. Alcoholism, Clinical and Experimental Research. 39: 962-8
Howard RJ, Trudell JR, Harris RA. (2014) Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics. Pharmacological Reviews. 66: 396-412
Heusser SA, Howard RJ, Borghese CM, et al. (2013) Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels. Molecular Pharmacology. 84: 670-8
Brömstrup T, Howard RJ, Trudell JR, et al. (2013) Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites. Structure (London, England : 1993). 21: 1307-16
Sauguet L, Howard RJ, Malherbe L, et al. (2013) Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nature Communications. 4: 1697
Spurny R, Billen B, Howard RJ, et al. (2013) Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). The Journal of Biological Chemistry. 288: 8355-64
Murail S, Howard RJ, Broemstrup T, et al. (2012) Molecular mechanism for the dual alcohol modulation of Cys-loop receptors. Plos Computational Biology. 8: e1002710
Johnson WD, Howard RJ, Trudell JR, et al. (2012) The TM2 6' position of GABA(A) receptors mediates alcohol inhibition. The Journal of Pharmacology and Experimental Therapeutics. 340: 445-56
Howard RJ, Murail S, Ondricek KE, et al. (2011) Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America. 108: 12149-54
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