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Rebecca J. Howard, Ph.D.

Affiliations: 
2007 Chemistry and Chemical Biology University of California, San Francisco, San Francisco, CA 
Area:
Channel Physiology
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"Rebecca Howard"
Mean distance: 15.68 (cluster 6)
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Dan Minor grad student 2007 UCSF
 (Structure and assembly properties of a conserved C-terminal domain in Kv7 channels.)

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Publications

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Bergh C, Rovšnik U, Howard R, et al. (2024) Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM. Elife. 12
Cowgill J, Fan C, Haloi N, et al. (2023) Structure and dynamics of differential ligand binding in the human ρ-type GABA receptor. Neuron
Bondarenko V, Chen Q, Singewald K, et al. (2023) Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization. Acs Chemical Neuroscience
Choudhury K, Howard RJ, Delemotte L. (2022) An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb. The Journal of General Physiology. 155
Lycksell M, Rovšnik U, Hanke A, et al. (2022) Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America. 119: e2210669119
Zhuang Y, Noviello CM, Hibbs RE, et al. (2022) Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208081119
Zhu S, Sridhar A, Teng J, et al. (2022) Structural and dynamic mechanisms of GABA receptor modulators with opposing activities. Nature Communications. 13: 4582
Choudhury K, Kasimova MA, McComas S, et al. (2021) An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine. Biophysical Journal
Bergh C, Heusser SA, Howard R, et al. (2021) Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel. Elife. 10
Lycksell M, Rovšnik U, Bergh C, et al. (2021) Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering. Proceedings of the National Academy of Sciences of the United States of America. 118
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