Ashley E. Brady, Ph.D.
Affiliations: | 2003 | Vanderbilt University, Nashville, TN |
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"Ashley Brady"Mean distance: 15.74 (cluster 11) | S | N | B | C | P |
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Sign in to add mentor| Lee Limbird | grad student | 2003 | Vanderbilt | |
| (Characterization of the interaction between alpha(2)-adrenergic receptors and spinophilin: A potential mechanism for stabilizing receptor at the cell surface.) | ||||
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Publications
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| Brady AE, Chen Y, Limbird LE, et al. (2011) Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology (Clifton, N.J.). 746: 347-55 |
| Davis AA, Heilman CJ, Brady AE, et al. (2010) Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation. Acs Chemical Neuroscience. 1: 542-551 |
| Shirey JK, Brady AE, Jones PJ, et al. (2009) A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14271-86 |
| Marlo JE, Niswender CM, Days EL, et al. (2009) Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Molecular Pharmacology. 75: 577-88 |
| Nicolle MM, Watson ML, McQuail JA, et al. (2009) P3-276: Acute administration of a novel M1 receptor allosteric potentiator (BQCA) restores reversal learning in a transgenic mouse model of Alzheimer's disease (Tg2576) Alzheimer's & Dementia. 5: P424-P424 |
| Jones CK, Brady AE, Davis AA, et al. (2008) Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10422-33 |
| Miller NR, Daniels RN, Bridges TM, et al. (2008) Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. Bioorganic & Medicinal Chemistry Letters. 18: 5443-7 |
| Bridges TM, Brady AE, Kennedy JP, et al. (2008) Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorganic & Medicinal Chemistry Letters. 18: 5439-42 |
| Brady AE, Jones CK, Bridges TM, et al. (2008) Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. The Journal of Pharmacology and Experimental Therapeutics. 327: 941-53 |
| Shirey JK, Xiang Z, Orton D, et al. (2008) An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nature Chemical Biology. 4: 42-50 |