Stephen Willingham, Ph.D.
Affiliations: | 2007 | Genetics & Molecular Biology | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
NeuroinflammationGoogle:
"Stephen Willingham"Mean distance: 19.07 (cluster 11)
Parents
Sign in to add mentor| Jenny P-Y Ting | grad student | 2007 | UNC Chapel Hill | |
| (Microbial pathogen-induced necrosis mediated by NLRP3 and ASC.) | ||||
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Publications
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| Davis BK, Roberts RA, Huang MT, et al. (2011) Cutting edge: NLRC5-dependent activation of the inflammasome. Journal of Immunology (Baltimore, Md. : 1950). 186: 1333-7 |
| Willingham SB, Allen IC, Bergstralh DT, et al. (2009) NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. Journal of Immunology (Baltimore, Md. : 1950). 183: 2008-15 |
| Duncan JA, Gao X, Huang MT, et al. (2009) Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. Journal of Immunology (Baltimore, Md. : 1950). 182: 6460-9 |
| Huang MT, Taxman DJ, Holley-Guthrie EA, et al. (2009) Critical role of apoptotic speck protein containing a caspase recruitment domain (ASC) and NLRP3 in causing necrosis and ASC speck formation induced by Porphyromonas gingivalis in human cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 2395-404 |
| Willingham SB, Ting JP. (2008) NLRs and the dangers of pollution and aging. Nature Immunology. 9: 831-3 |
| Li H, Willingham SB, Ting JP, et al. (2008) Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. Journal of Immunology (Baltimore, Md. : 1950). 181: 17-21 |
| Ting JP, Willingham SB, Bergstralh DT. (2008) NLRs at the intersection of cell death and immunity. Nature Reviews. Immunology. 8: 372-9 |
| Willingham SB, Bergstralh DT, O'Connor W, et al. (2007) Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host & Microbe. 2: 147-59 |
| Duncan JA, Bergstralh DT, Wang Y, et al. (2007) Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 8041-6 |