Adam S. Crystal, Ph.D.
Affiliations: | 2005 | University of Pennsylvania, Philadelphia, PA, United States |
Area:
tau, dementia, neurodegenerationGoogle:
"Adam Crystal"Mean distance: 16.53 (cluster 24) | S | N | B | C | P |
Parents
Sign in to add mentor| Virginia Man-Yee Lee | grad student | 2005 | Penn | |
| (Amyloid beta generation: Towards understanding the role of Pen-2 in the gamma-secretase complex, and, A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114.) | ||||
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Publications
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| Jhaveri K, Juric D, Cresta S, et al. (2020) Abstract P4-10-07: Tumor ER protein modulation, molecular characterization and monitoring of cfDNA in phase 1 study of LSZ102 and LSZ102 + ribociclib in patients with ER+ MBC Cancer Research. 80 |
| Jhaveri K, Curigliano G, Yap Y, et al. (2019) Abstract PD1-08: Phase 1/1b study of novel oral selective estrogen receptor degrader (SERD) LSZ102 for estrogen receptor-positive (ER+) advanced breast cancer (ABC) with progression on endocrine therapy (ET) Cancer Research. 79 |
| Curigliano G, Cresta S, Yap Y, et al. (2019) Abstract OT1-03-01: Phase 1/1b study of novel oral selective estrogen receptor degrader (SERD) LSZ102 in combination with alpelisib (BYL719) in estrogen receptor-positive (ER+), human epidermal growth factor receptor-2–negative (HER2–) advanced breast cancer (ABC) with progression on endocrine therapy (ET) Cancer Research. 79 |
| Gaither LA, Yip CLT, Wang C, et al. (2019) Abstract 922: Preclinical anticancer activity of LSZ102, a novel oral selective estrogen receptor degrader targeting wild-type and mutant ER Cancer Research. 79: 922-922 |
| Juric D, Curigliano G, Cresta S, et al. (2018) Abstract P5-21-04: Phase I/Ib study of the SERD LSZ102 alone or in combination with ribociclib in ER+ breast cancer Cancer Research. 78 |
| Morais VA, Brito C, Pijak DS, et al. (2006) N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53. Biochimica Et Biophysica Acta. 1762: 802-10 |
| Crystal AS, Morais VA, Fortna RR, et al. (2004) Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation. Biochemistry. 43: 3555-63 |
| Fortna RR, Crystal AS, Morais VA, et al. (2004) Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex. The Journal of Biological Chemistry. 279: 3685-93 |
| Fortna RR, Schaller N, Morais VA, et al. (2004) P4-319 Assembly, trafficking, and activity of the gamma-secretase complex Neurobiology of Aging. 25: S566 |
| Crystal AS, Giasson BI, Crowe A, et al. (2003) A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. Journal of Neurochemistry. 86: 1359-68 |