James H. Soper, Ph.D.

2008 University of Pennsylvania, Philadelphia, PA, United States 
tau, dementia, neurodegeneration
"James Soper"
Mean distance: 16.53 (cluster 24)


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Virginia Man-Yee Lee grad student 2008 Penn
 (Characterization of alpha-synuclein-induced vesicular accumulation in a yeast model of Parkinson's disease.)
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Soper JH, Sugiyama S, Herbst-Robinson K, et al. (2012) Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease. Acs Chemical Neuroscience. 3: 928-40
Ballatore C, Soper JH, Piscitelli F, et al. (2011) Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists. Journal of Medicinal Chemistry. 54: 6969-83
Lim Y, Kehm VM, Lee EB, et al. (2011) α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10076-87
Soper JH, Kehm V, Burd CG, et al. (2011) Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis. Journal of Molecular Neuroscience : Mn. 43: 391-405
Soper JH, Roy S, Stieber A, et al. (2008) Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Molecular Biology of the Cell. 19: 1093-103
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