John Hines, Ph.D.
Affiliations: | 2000 | University of Pennsylvania, Philadelphia, PA, United States |
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"John Hines"Mean distance: 18.21 (cluster 19) | S | N | B | C | P |
Parents
Sign in to add mentor| Steven J. Fluharty | grad student | 2000 | Penn | |
| (Structural determinants for functional properties of angiotensin II receptors.) | ||||
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Publications
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| Hines J, Gough JD, Corson TW, et al. (2013) Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs. Proceedings of the National Academy of Sciences of the United States of America. 110: 8942-7 |
| Hines J, Fluharty SJ, Yee DK. (2003) Structural determinants for the activation mechanism of the angiotensin II type 1 receptor differ for phosphoinositide hydrolysis and mitogen-activated protein kinase pathways. Biochemical Pharmacology. 66: 251-62 |
| Hines J, Fluharty SJ, Yee DK. (2001) Chimeric AT1/AT2 receptors reveal functional similarities despite key amino acid dissimilarities in the domains mediating agonist-dependent activation. Biochemistry. 40: 11251-60 |
| Hines J, Heerding JN, Fluharty SJ, et al. (2001) Identification of angiotensin II type 2 (AT2) receptor domains mediating high-affinity CGP 42112A binding and receptor activation. The Journal of Pharmacology and Experimental Therapeutics. 298: 665-73 |
| Heerding JN, Hines J, Fluharty SJ, et al. (2001) Identification and function of disulfide bridges in the extracellular domains of the angiotensin II type 2 receptor. Biochemistry. 40: 8369-77 |
| Peng H, Moffett J, Myers J, et al. (2001) Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors. Molecular Biology of the Cell. 12: 449-62 |
| Hines J, Fluharty SJ, Sakai RR. (1999) The angiotensin AT(1) receptor antagonist irbesartan has near-peptide affinity and potently blocks receptor signaling. European Journal of Pharmacology. 384: 81-9 |
| Yee DK, He P, Yang XD, et al. (1997) Cloning and expression of angiotensin II type 2 (AT2) receptors from murine neuroblastoma N1E-115 cells: evidence for AT2 receptor heterogeneity. Brain Research. Molecular Brain Research. 45: 108-16 |
| Raynor K, Kong H, Law S, et al. (1996) Molecular biology of opioid receptors. Nida Research Monograph. 161: 83-103 |
| Raynor K, Kong H, Hines J, et al. (1994) Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor Journal of Pharmacology and Experimental Therapeutics. 270: 1381-1386 |