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Joseph Bryan, PhD, University of Pennsylvania

Cell Biology Pacific Northwest Diabetes Research Institute, Seattle, WA, United States 
Cell Biology
"Joseph Bryan"

Mean distance: 15.69 (cluster 28)
Cross-listing: Cell Biology Tree


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Robert A Edwards grad student 1991-1995 Baylor College of Medicine (Cell Biology Tree)
George Perry post-doc 1979-1982
Lynne M. Coluccio post-doc 1985-1986 Baylor College of Medicine (Cell Biology Tree)
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Sikimic J, McMillen TS, Bleile C, et al. (2018) ATP-binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate K channels. The Journal of Biological Chemistry
Kurland DB, Gerzanich V, Karimy JK, et al. (2016) The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia. Journal of Neuroinflammation. 13: 130
Ortiz D, Bryan J. (2015) Neonatal Diabetes and Congenital Hyperinsulinism Caused by Mutations in ABCC8/SUR1 are Associated with Altered and Opposite Affinities for ATP and ADP. Frontiers in Endocrinology. 6: 48
Nakamura Y, Bryan J. (2014) Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells. Plos One. 9: e91525
Ortiz D, Gossack L, Quast U, et al. (2013) Reinterpreting the action of ATP analogs on K(ATP) channels. The Journal of Biological Chemistry. 288: 18894-902
Ortiz D, Voyvodic P, Gossack L, et al. (2012) Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2. The Journal of Biological Chemistry. 287: 17985-95
Su Y, Lam TK, He W, et al. (2012) Hypothalamic leucine metabolism regulates liver glucose production. Diabetes. 61: 85-93
Winkler M, Kühner P, Russ U, et al. (2012) Role of the amino-terminal transmembrane domain of sulfonylurea receptor SUR2B for coupling to K(IR)6.2, ligand binding, and oligomerization. Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 287-98
Kühner P, Prager R, Stephan D, et al. (2012) Importance of the Kir6.2 N-terminus for the interaction of glibenclamide and repaglinide with the pancreatic K(ATP) channel. Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 299-311
Gier B, Krippeit-Drews P, Sheiko T, et al. (2009) Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress. The Journal of Clinical Investigation. 119: 3246-56
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