Yi Liu

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Parsons WH, Calvo RR, Cheung W, et al. (2015) Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). Journal of Medicinal Chemistry. 58: 3859-74
Liu Y. (2014) Electrophysiological Studies of Voltage-Gated Sodium Channels Using QPatch HT, an Automated Patch-Clamp System. Current Protocols in Pharmacology. 65: 11.14.1-45
Winters MP, Subasinghe N, Wall M, et al. (2014) Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 2057-61
Winters MP, Subasinghe N, Wall M, et al. (2014) Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel. Bioorganic & Medicinal Chemistry Letters. 24: 2053-6
McComsey DF, Smith-Swintosky VL, Parker MH, et al. (2013) Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). Journal of Medicinal Chemistry. 56: 9019-30
Xu XH, Sun HY, Zhang YH, et al. (2012) Allitridi inhibits multiple cardiac potassium channels expressed in HEK 293 cells. Plos One. 7: e51550
Liu Y, Beck EJ, Flores CM. (2011) Validation of a patch clamp screening protocol that simultaneously measures compound activity in multiple states of the voltage-gated sodium channel Nav1.2. Assay and Drug Development Technologies. 9: 628-34
Finley MF, Lubin ML, Neeper MP, et al. (2010) An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists. Assay and Drug Development Technologies. 8: 685-94
Parker MH, Smith-Swintosky VL, McComsey DF, et al. (2009) Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. Journal of Medicinal Chemistry. 52: 7528-36
Mathes C, Friis S, Finley M, et al. (2009) QPatch: the missing link between HTS and ion channel drug discovery. Combinatorial Chemistry & High Throughput Screening. 12: 78-95