Ashley Lepack

Affiliations: 
2015- Pharmacology & Systems Therapeutics Icahn School of Medicine at Mount Sinai, New York, NY, United States 
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"Ashley Lepack"
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Fulton SL, Mitra S, Lepack AE, et al. (2022) Histone H3 dopaminylation in ventral tegmental area underlies heroin-induced transcriptional and behavioral plasticity in male rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Lepack AE, Werner CT, Stewart AF, et al. (2020) Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking. Science (New York, N.Y.). 368: 197-201
Werner CT, Mitra S, Martin JA, et al. (2019) Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving. Science Advances. 5: eaay0351
Lorsch ZS, Hamilton PJ, Ramakrishnan A, et al. (2019) Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex. Nature Neuroscience
Farrelly LA, Thompson RE, Zhao S, et al. (2019) Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature
Heshmati M, Aleyasin H, Menard C, et al. (2018) Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility. Proceedings of the National Academy of Sciences of the United States of America
Lorsch Z, Hamilton P, Lepack A, et al. (2018) O41. CREB-Zfp189 Interactions Regulate a Resilient-Specific Transcriptional Network in Animal Models of Depression Biological Psychiatry. 83: S125
Lepack AE, Bagot RC, Peña CJ, et al. (2016) Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior. Proceedings of the National Academy of Sciences of the United States of America
Dwyer JM, Maldonado-Avilés JG, Lepack AE, et al. (2015) Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior. Proceedings of the National Academy of Sciences of the United States of America. 112: 6188-93
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