Heather A. Arnett

Affiliations: 
Amgen Inc., Thousand Oaks, CA, United States 
Area:
Neuroinflammation, multiple sclerosis
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"Heather Arnett"
Mean distance: 18.03 (cluster 32)
 

Parents

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Jenny P-Y Ting grad student 1997-2002 UNC Chapel Hill
 (The role of inflammation in demyelination and remyelination in the CNS.)
Charles D. Stiles post-doc 2002-2004 Harvard Medical School
 (Dana Farber Cancer Institute)
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Publications

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Dietrich D, Martin P, Flacher V, et al. (2016) Interleukin-36 potently stimulates human M2 macrophages, Langerhans cells and keratinocytes to produce pro-inflammatory cytokines. Cytokine. 84: 88-98
Doody KM, Stanford SM, Sacchetti C, et al. (2015) Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy Science Translational Medicine. 7
Arnett HA, Viney JL. (2014) Immune modulation by butyrophilins. Nature Reviews. Immunology. 14: 559-69
Swanson RM, Gavin MA, Escobar SS, et al. (2013) Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells. Journal of Immunology (Baltimore, Md. : 1950). 190: 2027-35
Stanford SM, Maestre MF, Campbell AM, et al. (2013) Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis and Rheumatism. 65: 1171-80
Harrington PE, Croghan MD, Fotsch C, et al. (2012) Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. Acs Medicinal Chemistry Letters. 3: 74-8
Pennington LD, Croghan MD, Sham KK, et al. (2012) Quinolinone-based agonists of S1P₁: use of a N-scan SAR strategy to optimize in vitro and in vivo activity. Bioorganic & Medicinal Chemistry Letters. 22: 527-31
Cee VJ, Frohn M, Lanman BA, et al. (2011) Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5. Acs Medicinal Chemistry Letters. 2: 107-12
Pennington LD, Sham KK, Pickrell AJ, et al. (2011) 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. Acs Medicinal Chemistry Letters. 2: 752-7
Weinger JG, Brosnan CF, Loudig O, et al. (2011) Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 8: 49
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