Hariharan Saminathan, Ph.D.

Affiliations: 
2011 Interdisciplinary Graduate Studies Iowa State University, Ames, IA, United States 
Area:
Neuroscience, Toxicology
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"Hariharan Saminathan"
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Anumantha G. Kanthasamy grad student 2011 Iowa State
 (Role of Fyn kinase in dopaminergic neuronal degeneration: Relevance to oxidative damage in Parkinson's disease.)
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Publications

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Saminathan H, Ghosh A, Zhang D, et al. (2021) Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson's Disease. Frontiers in Pharmacology. 12: 631375
Saminathan H, Charli A, Luo J, et al. (2020) Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. European Journal of Pharmacology. 173259
Panicker N, Sarkar S, Harischandra DS, et al. (2019) Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. The Journal of Experimental Medicine
Panicker N, Saminathan H, Jin H, et al. (2015) Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10058-77
Ghosh A, Saminathan H, Kanthasamy A, et al. (2013) The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 288: 21955-71
Saminathan H, Asaithambi A, Anantharam V, et al. (2011) Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model. Neurotoxicology. 32: 567-77
Asaithambi A, Kanthasamy A, Saminathan H, et al. (2011) Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Molecular Neurodegeneration. 6: 43
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