Phillip Needleman

Affiliations: 
Washington University School of Medicine, St. Louis, MO, United States 
Area:
prostaglandins, cyclooxygenase, COX inhibitors
Google:
"Phillip Needleman"
Mean distance: 15.9 (cluster 32)
 
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Publications

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Levin G, Duffin KL, Obukowicz MG, et al. (2002) Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. The Biochemical Journal. 365: 489-96
Duffin KL, Obukowicz MG, Salsgiver WJ, et al. (2001) Lipid remodeling in mouse liver and plasma resulting from delta6 fatty acid desaturase inhibition. Lipids. 36: 1203-8
Needleman P. (2001) From a twinkle in the eye to a blockbuster drug Research Technology Management. 44: 38-39+41
Masferrer JL, Needleman P. (2000) Anti-inflammatories for cardiovascular disease. Proceedings of the National Academy of Sciences of the United States of America. 97: 12400-1
Needleman P, Manning PT. (1999) Interactions between the inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) pathways: implications for therapeutic intervention in osteoarthritis. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 7: 367-70
Obukowicz M, Welsch D, Salsgiver W, et al. (1999) Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. Lipids. 34: S149
Seibert K, Lefkowith J, Tripp C, et al. (1999) COX-2 inhibitors--is there cause for concern? Nature Medicine. 5: 621-2
Obukowicz MG, Welsch DJ, Salsgiver WJ, et al. (1998) Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. The Journal of Pharmacology and Experimental Therapeutics. 287: 157-66
Obukowicz MG, Raz A, Pyla PD, et al. (1998) Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochemical Pharmacology. 55: 1045-58
Venturini CM, Isakson P, Needleman P. (1998) Non-steroidal anti-inflammatory drug-induced renal failure: a brief review of the role of cyclo-oxygenase isoforms. Current Opinion in Nephrology and Hypertension. 7: 79-82
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