Shelly Allen

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Shoemark DK, Williams C, Fahey MS, et al. (2015) Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery. Journal of Medicinal Chemistry. 58: 767-77
Allen SJ, Watson JJ, Shoemark DK, et al. (2013) GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacology & Therapeutics. 138: 155-75
Frias B, Allen S, Dawbarn D, et al. (2013) Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation. Neuroscience. 234: 88-102
Allen SJ, Watson JJ, Dawbarn D. (2011) The neurotrophins and their role in Alzheimer's disease. Current Neuropharmacology. 9: 559-73
McNamee KE, Burleigh A, Gompels LL, et al. (2010) Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain. 149: 386-92
Pinto R, Frias B, Allen S, et al. (2010) Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis. Neuroscience. 166: 907-16
Masoudi R, Ioannou MS, Coughlin MD, et al. (2009) Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors. The Journal of Biological Chemistry. 284: 18424-33
Watson JJ, Allen SJ, Dawbarn D. (2008) Targeting nerve growth factor in pain: what is the therapeutic potential? Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 22: 349-59
Clewes O, Fahey MS, Tyler SJ, et al. (2008) Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin. Journal of Neurochemistry. 107: 1124-35
Hatchett CS, Tyler S, Armstrong D, et al. (2007) Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro. Brain Research. 1147: 248-55