Graeme Bilbe

Affiliations: 
Novartis, Basel, Basel-Stadt, France 
Website:
http://nibr.novartis.com/About/Scientific_leaders/bilbe.shtml
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"Graeme Bilbe"
Mean distance: 17.01 (cluster 11)
 
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Publications

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Feuerbach D, Pezous N, Weiss M, et al. (2015) AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation. British Journal of Pharmacology. 172: 1292-304
Vranesic I, Ofner S, Flor PJ, et al. (2014) AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization. Bioorganic & Medicinal Chemistry. 22: 5790-803
Weiss A, Träger U, Wild EJ, et al. (2012) Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression. The Journal of Clinical Investigation. 122: 3731-6
Grégoire L, Morin N, Ouattara B, et al. (2011) The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in L-Dopa-treated parkinsonian monkeys. Parkinsonism & Related Disorders. 17: 270-6
Jacquemont S, Curie A, des Portes V, et al. (2011) Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056. Science Translational Medicine. 3: 64ra1
Ouattara B, Grégoire L, Morissette M, et al. (2011) Metabotropic glutamate receptor type 5 in levodopa-induced motor complications. Neurobiology of Aging. 32: 1286-95
Moscovitch-Lopatin M, Weiss A, Rosas HD, et al. (2010) Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease. Plos Currents. 2: RRN1205
Weiss A, Abramowski D, Bibel M, et al. (2009) Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease. Analytical Biochemistry. 395: 8-15
Feuerbach D, Lingenhoehl K, Olpe HR, et al. (2009) The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain. Neuropharmacology. 56: 254-63
Gasparini F, Bilbe G, Gomez-Mancilla B, et al. (2008) mGluR5 antagonists: discovery, characterization and drug development. Current Opinion in Drug Discovery & Development. 11: 655-65
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