James A. Joseph, PhD, University of South Carolina

USDA Human Nutrition Research Center on Aging Tufts University, Boston 
Mechanisms involved in brain aging and vulnerability to oxidative stress and inflammation; nutritional modulation of this sensitivity
"James Joseph"



Dr. Joseph received his Ph.D. in Behavioral Neuroscience from the University of South Carolina in 1976. He was a post-doctoral fellow at the Gerontology Research Center/NIH from 1976-1982, and a senior scientist at Lederle Research Laboratories from 1982-1985 when he joined the Armed Forces Radiobiology Institute. In 1988 he returned to the GRC as a senior scientist and in 1993 joined USDA Human Nutrition Research Center on Aging at Tufts University as the Director of the Neuroscience Laboratory.

He is the author or co-author of 250 scientific publications and has shared in the Sandoz Award in Gerontology, received a JAFEH fellowship from the National Institute for Longevity Science in Japan, the Stephanie Overstreet award in Alzheimer Research from the Alzheimer Foundation, the Alex Wetherbee Award from the North American Blueberry Council, the 2002 Glenn Foundation Award for Aging Research, the 2004 Harman Research Award, and the 2005 International Award for Modern Nutrition from the Swiss Milk Producers, the 2007 North Atlantic Area USDA Agricultural Research Service Scientist of the Year Award, and the 2009 SmithKlineGlaxo award for polyphenol research.

He also serves on the editorial review boards for the following journals: Experimental Gerontology, Aging Cell, Neurobiology of Aging and Current Topics in Nutraceutical Research. His book, The Color Code: A Revolutionary Eating Plan for Optimum Health which is concerned with the health benefits of colorful fruits and vegetables, has been translated into five languages. Numerous nutrition programs promoting a “colorful” diet such as 5 A Day the Color way have utilized this book in advocating a healthier diet.
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Mean distance: 18.93 (cluster 28)
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Miller MG, Hamilton DA, Joseph JA, et al. (2017) Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. European Journal of Nutrition
Shukitt-Hale B, Bielinski DF, Lau FC, et al. (2015) The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. The British Journal of Nutrition. 114: 1542-9
Shukitt-Hale B, Miller MG, Chu YF, et al. (2013) Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. Age (Dordrecht, Netherlands). 35: 2183-92
Carey AN, Fisher DR, Joseph JA, et al. (2013) The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. Nutritional Neuroscience. 16: 13-20
Shukitt-Hale B, Lau FC, Cheng V, et al. (2013) Changes in gene expression in the rat hippocampus following exposure to 56Fe particles and protection by berry diets. Central Nervous System Agents in Medicinal Chemistry. 13: 36-42
Joseph JA, Casadesus G, Smith MA, et al. (2013) Nutrients and Food Constituents in Cognitive Decline and Neurodegenerative Disease Nutrition in the Prevention and Treatment of Disease. 373-390
Chang J, Rimando A, Pallas M, et al. (2012) Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiology of Aging. 33: 2062-71
Rabin BM, Joseph JA, Shukitt-Hale B, et al. (2012) Interaction between age of irradiation and age of testing in the disruption of operant performance using a ground-based model for exposure to cosmic rays. Age (Dordrecht, Netherlands). 34: 121-31
Elks CM, Reed SD, Mariappan N, et al. (2011) A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress. Plos One. 6: e24028
Malin DH, Lee DR, Goyarzu P, et al. (2011) Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats. Nutrition (Burbank, Los Angeles County, Calif.). 27: 338-42
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