Pasha Grachev, Ph.D.

2009-2013 Division of Women's Health King's College London, London, UK 
 2013-2016 Physiology & Pharmacology West Virgina University 
 2016- Physiology & Pharmacology Oregon Health and Science University, Portland, OR 
Neuroendocrinology, neuroscience, endocrinology
"Pasha Grachev neuroendocrinology"

I am a passionate young neuroendocrinologist with substantial experience in in vivo basic research on various aspects of hypothalamic regulation of reproductive function, as well as a desire to discover effective, non-invasive treatments targeting neural pathways implicated in metabolic syndrome and obesity. I routinely employ optogenetic, neuropharmacological and imaging techniques to address functional relationships between hypothalamic neurons, their afferent inputs, and feeding behavior. Outside of the lab, I am an aspiring musician, currently leading an original post-funk band. However, my favourite pastime is to embark upon adventures in the wilder parts of the world, which I traverse preferentially by motorcycle.

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Fergani C, Mazzella L, Coolen LM, et al. (2016) Do Substance P and Neurokinin A Play Important Roles in the Control of LH Secretion in Ewes? Endocrinology. en20161565
Grachev P, Porter KL, Coolen LM, et al. (2016) Surge-like LH secretion induced by retrochiasmatic area NK3R activation is mediated primarily by ARC kisspeptin neurones in the ewe. Journal of Neuroendocrinology
Grachev P, Li XF, Goffin V, et al. (2015) Hypothalamic Prolactin Regulation of Luteinizing Hormone Secretion in the Female Rat. Endocrinology. 156: 2880-92
Grachev P, Li XF, Hu MH, et al. (2014) Neurokinin B signaling in the female rat: a novel link between stress and reproduction. Endocrinology. 155: 2589-601
Grachev P, Millar RP, O'Byrne KT. (2014) The role of neurokinin B signalling in reproductive neuroendocrinology. Neuroendocrinology. 99: 7-17
Grachev P, Li XF, O'Byrne K. (2013) Stress regulation of kisspeptin in the modulation of reproductive function. Advances in Experimental Medicine and Biology. 784: 431-54
Grachev P, Li XF, Lin YS, et al. (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Plos One. 7: e44344
Grachev P, Li XF, Kinsey-Jones JS, et al. (2012) Suppression of the GnRH pulse generator by neurokinin B involves a κ-opioid receptor-dependent mechanism. Endocrinology. 153: 4894-904
Kinsey-Jones JS, Grachev P, Li XF, et al. (2012) The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat. Endocrinology. 153: 307-15
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