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Ju-hyun Lee

Affiliations: 
Psychiatry/Center for Dementia Research NYU/Nathan Kline Institute for psychiatry research, Orangeburg, NY, United States 
Area:
Alzheimer's disease, Autophagy, Transport
Google:
"Ju-hyun Lee"
Mean distance: 20.23 (cluster 50)
 
Cross-listing: Alzheimer's Tree

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Parents

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Declan M. McLoughlin grad student Institute of Psychiatry, King's College London
Christopher C.J. Miller grad student Institute of Psychiatry, King's College London
Seung R. Paik grad student Inha University College of Medicine, Korea
Ralph A. Nixon post-doc Nathan Kline Institute, New York University Medical School

Children

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Collaborators

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Publications

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Im E, Jiang Y, Stavrides PH, et al. (2023) Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr-phosphorylated APP βCTF. Science Advances. 9: eadg1925
Rao MV, Darji S, Stavrides PH, et al. (2022) Autophagy is a novel pathway for neurofilament protein degradation . Autophagy. 1-16
Lee JH, Nixon RA. (2022) Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis. Autophagy. 1-2
Lee JH, Yang DS, Goulbourne CN, et al. (2022) Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nature Neuroscience. 25: 688-701
Lie PPY, Yoo L, Goulbourne CN, et al. (2022) Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca efflux and disrupted by PSEN1 loss of function. Science Advances. 8: eabj5716
Pensalfini A, Kim S, Subbanna S, et al. (2020) Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell Reports. 33: 108420
Lee JH, Wolfe DM, Darji S, et al. (2020) β2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7. Journal of Molecular Biology
Klionsky DJ, Abdelmohsen K, Abe A, et al. (2016) Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443
Klionsky DJ, Abdelmohsen K, Abe A, et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222
Lee JH, McBrayer MK, Wolfe DM, et al. (2015) Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification. Cell Reports
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