Ralph A. Nixon, MD

Affiliations: 
Psychiatry New York University, New York, NY, United States 
Area:
neurodegeneration, Alzheimer's disease, Autophagy
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"Ralph Nixon"
Bio:

NYU SCH MED NATHAN KLINE INST
PSYCHIATRIC RES DEPT
140 OLD ORANGEBURG RD
ORANGEBURG, NY 109621157
United States

Mean distance: 18.25 (cluster 50)
 
Cross-listing: Alzheimer's Tree

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Publications

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Bordi M, Darji S, Sato Y, et al. (2019) mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy. Cell Death & Disease. 10: 563
Ying J, Sato Y, Im E, et al. (2019) Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Ju-Hyun L, Rao MV, Yang DS, et al. (2018) Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. Autophagy
Colacurcio DJ, Pensalfini A, Jiang Y, et al. (2017) Dysfunction of Autophagy and Endosomal-lysosomal Pathways: Roles in Pathogenesis of Down Syndrome and Alzheimer's Disease. Free Radical Biology & Medicine
Yang DS, Stavrides P, Kumar A, et al. (2017) Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice. Human Molecular Genetics
Bordi M, Berg MJ, Mohan PS, et al. (2016) Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy. 1-17
Colacurcio DJ, Nixon RA. (2016) Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Research Reviews
Jiang Y, Rigoglioso A, Peterhoff CM, et al. (2016) Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiology of Aging. 39: 90-98
Klionsky DJ, Abdelmohsen K, Abe A, et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222
Rao MV, Campbell J, Palaniappan A, et al. (2016) Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice. Journal of Neurochemistry
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