Matthew A. Seager, Ph.D.

2005-2009 Merck & Co., Inc. 
 2009-2014 Bristol-Myers Squibb Company, New York, NY, United States 
 2017- Yale University, New Haven, CT 
Alzheimer's disease, schizophrenia, depression, learning, memory, cognition, drugs of abuse, hippocampus
"Matthew Seager"
Mean distance: 14.99 (cluster 17)
Cross-listing: Alzheimer's Tree


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Stephen D. Berry grad student 1993-1999 Miami University
Bernard G. Schreurs post-doc 1999-2002
Kurt Rasmussen post-doc 2002-2005
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Balcer OM, Seager MA, Gleason SD, et al. (2018) Evaluation of 5-HT receptor antagonism for the treatment of anxiety, depression, and schizophrenia through the use of receptor-deficient mice. Behavioural Brain Research. 360: 270-278
Higgins MA, Marcin LR, Christopher Zusi F, et al. (2016) Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia. Bioorganic & Medicinal Chemistry
Kuduk SD, Chang RK, Di Marco CN, et al. (2011) Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold. Journal of Medicinal Chemistry. 54: 4773-80
Ma L, Seager MA, Seager M, et al. (2009) Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proceedings of the National Academy of Sciences of the United States of America. 106: 15950-5
Asaka Y, Mauldin KN, Griffin AL, et al. (2005) Nonpharmacological amelioration of age-related learning deficits: the impact of hippocampal theta-triggered training. Proceedings of the National Academy of Sciences of the United States of America. 102: 13284-8
Seager MA, Barth VN, Phebus LA, et al. (2005) Chronic coadministration of olanzapine and fluoxetine activates locus coeruleus neurons in rats: implications for bipolar disorder. Psychopharmacology. 181: 126-33
Rasmussen K, Martin H, Berger JE, et al. (2005) The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats. Neuropharmacology. 48: 173-80
Huff KD, Asaka Y, Griffin AL, et al. (2004) Differential mastication kinematics of the rabbit in response to food and water: implications for conditioned movement. Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society. 39: 16-23
Seager MA, Huff KD, Barth VN, et al. (2004) Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity. Biological Psychiatry. 55: 1103-9
Seager MA, Smith-Bell CA, Schreurs BG. (2003) Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response: US intensity effects. Learning & Behavior. 31: 292-8
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