Michelle E. Kimple, Ph.D.
Affiliations: | 2003 | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
Biochemistry, General Biophysics, Molecular BiologyGoogle:
"Michelle Kimple"Parents
Sign in to add mentor| John E. Sondek | grad student | 2003 | UNC Chapel Hill | |
| (Structural determinants of PDZ domain interaction with phospholipase C-beta isozymes.) | ||||
Children
Sign in to add trainee| Allison L. Brill | research assistant | 2012-2014 | UW Madison (Neurotree) |
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Publications
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| Neuman JC, Reuter A, Carbajal KA, et al. (2024) The Prostaglandin E EP3 Receptor Has Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model of Obesity. American Journal of Physiology. Endocrinology and Metabolism |
| Schaid MD, Harrington JM, Kelly GM, et al. (2023) EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance. Islets. 15: 2223327 |
| Fenske RJ, Weeks AM, Daniels M, et al. (2022) Plasma Prostaglandin E Metabolite Levels Predict Type 2 Diabetes Status and One-Year Therapeutic Response Independent of Clinical Markers of Inflammation. Metabolites. 12 |
| Bosma KJ, Kaiser CE, Kimple ME, et al. (2022) Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass. Metabolites. 12 |
| Bosma KJ, Andrei SR, Katz LS, et al. (2021) Pharmacological blockade of the EP3 prostaglandin E receptor in the setting of Type 2 diabetes enhances β-cell proliferation and identity, and relieves oxidative damage. Molecular Metabolism. 101347 |
| Truchan NA, Fenske RJ, Sandhu HK, et al. (2021) Human Islet Expression Levels of Prostaglandin E Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity. Acs Pharmacology & Translational Science. 4: 1338-1348 |
| Wisinski J, Reuter A, Peter DC, et al. (2021) Prostaglandin EP3 Receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance. American Journal of Physiology. Endocrinology and Metabolism |
| Sandhu HK, Neuman JC, Schaid MD, et al. (2021) Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion. Pharmacology Research & Perspectives. 9: e00736 |
| Schaid MD, Zhu Y, Richardson NE, et al. (2021) Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes. Metabolites. 11 |
| Schaid MD, Green CL, Peter DC, et al. (2020) Agonist-independent Gα activity negatively regulates β-cell compensation in a diet-induced obesity model of type 2 diabetes. The Journal of Biological Chemistry |