Frederick Streeter Barrett, Ph.D.

2013- Center for Psychedelic and Consciousness Research Johns Hopkins University School of Medicine, Baltimore, MD, United States 
 2013- Behavioral Pharmacology Research Unit Johns Hopkins University School of Medicine, Baltimore, MD, United States 
 2013- Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Psychedelics, Music, Affective & Cognitive Neuroscience
"Frederick Streeter Barrett"

Frederick Barrett is a cognitive neuroscientist with training in behavioral pharmacology. Dr. Barrett has been conducting psychedelic research at Johns Hopkins University since 2013, and his research in heathy participants and in patients with mood and substance use disorders focuses on the psychological and neurological mechanisms underlying the enduring therapeutic and other effects of psychedelic drugs. In 2017, he received an NIH “R03” grant as Principal Investigator to investigate biological mechanisms of psilocybin effects, the first federally funded research since the 1970s administering a classic psychedelic to people with psychedelic effects as the primary focus. He developed the first comprehensive questionnaire to measure subjective aspects of challenging experiences encountered with psilocybin. He also published the first studies in humans characterizing the enduring effects of psilocybin on the brain (up to a month after psilocybin administration), the effects of psilocybin on a brain structure called the claustrum (which has been proposed to variously mediate consciousness and cognition), the effects of LSD on the brain's response to music, and the effects of the atypical hallucinogen salvinorin A on human brain network function. He is currently leading a clinical trial to investigate the use of psilocybin to treat patients with major depressive disorder and co-occurring alcohol use disorder, and he is leading a number of ongoing studies aimed at better understanding the psychological, biological, and neural mechanisms underlying therapeutic efficacy of psychedelic drugs.
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Lauren B. Alloy research assistant 2002-2004 Temple University
Robert W. Weisberg research assistant 2002-2004 Temple University
Ruben C. Gur research assistant 2004-2007 Penn
Petr Janata grad student 2007-2013 UC Davis
 (A Multi-Level Model of Music-Evoked Emotions: Stimulus Features, Personality, Familiarity, and Liking.)
Richard W. Robins grad student 2007-2013 UC Davis (PsychTree)
J. Daniel Ragland grad student 2012-2013 UC Davis
Roland Griffiths post-doc 2013- Johns Hopkins Medical School
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Doss MK, Madden MB, Gaddis A, et al. (2021) Models of psychedelic drug action: modulation of cortical-subcortical circuits. Brain : a Journal of Neurology
Doss MK, Považan M, Rosenberg MD, et al. (2021) Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder. Translational Psychiatry. 11: 574
Nayak SM, Gukasyan N, Barrett FS, et al. (2021) Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports. Pharmacopsychiatry
Yaden DB, Johnson MW, Griffiths RR, et al. (2021) Psychedelics and Consciousness: Distinctions, Demarcations, and Opportunities. The International Journal of Neuropsychopharmacology
Garcia-Romeu A, Barrett FS, Carbonaro TM, et al. (2021) Optimal dosing for psilocybin pharmacotherapy: Considering weight-adjusted and fixed dosing approaches. Journal of Psychopharmacology (Oxford, England). 269881121991822
Davis AK, Barrett FS, So S, et al. (2021) Development of the Psychological Insight Questionnaire among a sample of people who have consumed psilocybin or LSD. Journal of Psychopharmacology (Oxford, England). 269881120967878
Davis AK, Barrett FS, May DG, et al. (2020) Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial. Jama Psychiatry
Doss MK, May DG, Johnson MW, et al. (2020) The Acute Effects of the Atypical Dissociative Hallucinogen Salvinorin A on Functional Connectivity in the Human Brain. Scientific Reports. 10: 16392
Davis AK, Barrett FS, Griffiths RR. (2020) Psychological flexibility mediates the relations between acute psychedelic effects and subjective decreases in depression and anxiety. Journal of Contextual Behavioral Science. 15: 39-45
Barrett FS, Doss MK, Sepeda ND, et al. (2020) Emotions and brain function are altered up to one month after a single high dose of psilocybin. Scientific Reports. 10: 2214
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