Kenneth Y. Kwan, Ph.D.

Affiliations: 
Neuroscience University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Cortical development, neural circuit assembly, neurodevelopmental disorders
Website:
http://www.kwanlab.org
Google:
"Kenneth Y. Kwan"
Bio:

Evolution of the cerebral cortex is thought to underlie our species’ most remarkable cognitive, perceptive, and motor capabilities, the execution of which depends on the precise establishment of connectivity during development. Miswiring of cortical circuitry can lead to disorders, including autism and schizophrenia, that affect the most distinctly human cognitive functions.

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Mean distance: 15.44 (cluster 11)
 
SNBCP
Cross-listing: MichiganTree

Parents

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Nenad Sestan grad student 2003-2008 Yale
 (SOX5 regulates migration, postmigratory differentiation, and axonal projections of subplate and deep-layer neocortical neurons.)
Nenad Sestan post-doc 2008-2013 Yale School of Medicine

Children

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Steven Colvin research assistant 2013- University of Michigan
Owen H. Funk research assistant 2013- University of Michigan
Jason Keil grad student
Daniel Z Doyle grad student 2016- University of Michigan
Lei Shi post-doc 2015- University of Michigan
BETA: Related publications

Publications

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Keil JM, Doyle DZ, Qalieh A, et al. (2020) Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nature Communications. 11: 3839
Bott CJ, McMahon LP, Keil JM, et al. (2020) Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Zhou W, Emery SB, Flasch DA, et al. (2019) Identification and characterization of occult human-specific LINE-1 insertions using long-read sequencing technology. Nucleic Acids Research
Shi L, Qalieh A, Lam MM, et al. (2019) Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nature Communications. 10: 2588
Keil JM, Qalieh A, Kwan KY. (2018) Brain transcriptome databases: a user's guide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
McConnell MJ, Moran JV, Abyzov A, et al. (2017) Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science (New York, N.Y.). 356
Akins MR, Berk-Rauch HE, Kwan KY, et al. (2017) Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains. Human Molecular Genetics
Caubit X, Gubellini P, Andrieux J, et al. (2016) TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons. Nature Genetics
Colvin SM, Kwan KY. (2014) Dysregulated nitric oxide signaling as a candidate mechanism of fragile X syndrome and other neuropsychiatric disorders. Frontiers in Genetics. 5: 239
Funk OH, Kwan KY. (2014) Nitric oxide signaling in the development and evolution of language and cognitive circuits. Neuroscience Research. 86: 77-87
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