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Kenneth Y. Kwan, Ph.D.

Affiliations: 
Neuroscience University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Cortical development, neural circuit assembly, neurodevelopmental disorders
Website:
http://www.kwanlab.org
Google:
"Kenneth Y. Kwan"
Bio:

Evolution of the cerebral cortex is thought to underlie our species’ most remarkable cognitive, perceptive, and motor capabilities, the execution of which depends on the precise establishment of connectivity during development. Miswiring of cortical circuitry can lead to disorders, including autism and schizophrenia, that affect the most distinctly human cognitive functions.

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Mean distance: 15.44 (cluster 11)
 		SNBCP
Cross-listing: MichiganTree

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Parents

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Nenad Sestan grad student 2003-2008 Yale
 (SOX5 regulates migration, postmigratory differentiation, and axonal projections of subplate and deep-layer neocortical neurons.)
Nenad Sestan post-doc 2008-2013 Yale School of Medicine

Children

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Steven Colvin research assistant 2013-2015 University of Michigan
Ikenna P Njoku grad student 2022- University of Michigan
Karina Hernandez Quijada grad student 2023- University of Michigan
Jason Keil grad student 2014-2019
Owen H. Funk grad student 2014-2021 University of Michigan
Daniel Doyle grad student 2016-2023 University of Michigan
Lei Shi post-doc 2015-2019 University of Michigan

Collaborators

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Publications

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Liao C, O'Farrell E, Qalieh Y, et al. (2025) Single-nucleus transcriptomics reveals time-dependent and cell-type-specific effects of psilocybin on gene expression. Biorxiv : the Preprint Server For Biology
Molnár Z, Kwan KY. (2024) Development and Evolution of Thalamocortical Connectivity. Cold Spring Harbor Perspectives in Biology. 16
Njoku IP, Kwan KY. (2023) Distinct microtubule networks mediate neuronal migration and polarization. Neuron. 111: 1168-1170
Funk OH, Qalieh Y, Doyle DZ, et al. (2022) Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity. Proceedings of the National Academy of Sciences of the United States of America. 119: e2116956119
Bae T, Fasching L, Wang Y, et al. (2022) Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability. Science (New York, N.Y.). 377: 511-517
Doyle DZ, Kwan KY. (2022) Neurogenic-angiogenic synchrony via lactate. Nature Neuroscience. 25: 839-840
Yang T, Veling MW, Zhao XF, et al. (2022) Migrating pyramidal neurons require DSCAM to bypass the border of the developing cortical plate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Doyle DZ, Lam MM, Qalieh A, et al. (2021) Chromatin remodeler regulates subplate neuron identity and wiring of cortical connectivity. Proceedings of the National Academy of Sciences of the United States of America. 118
Keil JM, Doyle DZ, Qalieh A, et al. (2020) Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nature Communications. 11: 3839
Bott CJ, McMahon LP, Keil JM, et al. (2020) Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
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