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David M. Holtzman

Neurology Washington University, Saint Louis, St. Louis, MO 
Alzheimer's, amyloid
"David Holtzman"

David Holtzman is the Andrew B. and Gretchen P. Jones Professor and Chairman of Neurology, Professor of Developmental Biology, Associate Director of the Alzheimer's Disease Research Center, and a member of the Hope Center for Neurological Disorders. A major interest in his lab is in understanding basic mechanisms underlying acute and chronic cell dysfunction in the CNS particularly as these mechanisms may relate to Alzheimer's disease (AD) and injury to the developing brain.

Mean distance: 14.48 (cluster 31)
Cross-listing: Alzheimer's Tree

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Davis AA, Inman CE, Wargel ZM, et al. (2020) genotype regulates pathology and disease progression in synucleinopathy. Science Translational Medicine. 12
Zhou Y, Song WM, Andhey PS, et al. (2020) Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease. Nature Medicine. 26: 131-142
Faraco G, Hochrainer K, Segarra SG, et al. (2020) Publisher Correction: Dietary salt promotes cognitive impairment through tau phosphorylation. Nature
Llibre-Guerra JJ, Li Y, Schindler SE, et al. (2019) Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease. Jama Network Open. 2: e1917126
Seo DO, Holtzman DM. (2019) Gut microbiota: from the forgotten organ to a potential key player in the pathology of Alzheimer disease. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences
Gallardo G, Wong CH, Ricardez SM, et al. (2019) Targeting tauopathy with engineered tau-degrading intrabodies. Molecular Neurodegeneration. 14: 38
Huynh TV, Wang C, Tran AC, et al. (2019) Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. Molecular Neurodegeneration. 14: 37
Shi Y, Manis M, Long J, et al. (2019) Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. The Journal of Experimental Medicine
Seo DO, Boros BD, Holtzman DM. (2019) The microbiome: A target for Alzheimer disease? Cell Research
Xu J, Sun J, Perrin RJ, et al. (2019) Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains. Annals of Clinical and Translational Neurology. 6: 1423-1434
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