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David M. Holtzman

Neurology Washington University, Saint Louis, St. Louis, MO 
Alzheimer's, amyloid
"David Holtzman"

David Holtzman is the Andrew B. and Gretchen P. Jones Professor and Chairman of Neurology, Professor of Developmental Biology, Associate Director of the Alzheimer's Disease Research Center, and a member of the Hope Center for Neurological Disorders. A major interest in his lab is in understanding basic mechanisms underlying acute and chronic cell dysfunction in the CNS particularly as these mechanisms may relate to Alzheimer's disease (AD) and injury to the developing brain.

Mean distance: 14.48 (cluster 31)
Cross-listing: Alzheimer's Tree

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Gratuze M, Schlachetzki JCM, D'Oliveira Albanus R, et al. (2022) TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron
Chen X, Holtzman DM. (2022) Emerging roles of innate and adaptive immunity in Alzheimer's disease. Immunity
Wang S, Sudan R, Peng V, et al. (2022) TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell. 185: 4153-4169.e19
Jain N, Lewis CA, Ulrich JD, et al. (2022) Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading. The Journal of Experimental Medicine. 220
Chen K, Martens YA, Meneses A, et al. (2022) LRP1 is a neuronal receptor for α-synuclein uptake and spread. Molecular Neurodegeneration. 17: 57
Wander CM, Tsujimoto THM, Ervin JF, et al. (2022) Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease. Acta Neuropathologica Communications. 10: 110
Schindler SE, Li Y, Li M, et al. (2022) Using Alzheimer's disease blood tests to accelerate clinical trial enrollment. Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Long JM, Coble DW, Xiong C, et al. (2022) Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes. Brain : a Journal of Neurology
Tcw J, Qian L, Pipalia NH, et al. (2022) Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 185: 2213-2233.e25
Capano LS, Sato C, Ficulle E, et al. (2022) Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons. Cell Stem Cell. 29: 918-932.e8
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