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David M. Holtzman

Neurology Washington University, Saint Louis, St. Louis, MO 
Alzheimer's, amyloid
"David Holtzman"

David Holtzman is the Andrew B. and Gretchen P. Jones Professor and Chairman of Neurology, Professor of Developmental Biology, Associate Director of the Alzheimer's Disease Research Center, and a member of the Hope Center for Neurological Disorders. A major interest in his lab is in understanding basic mechanisms underlying acute and chronic cell dysfunction in the CNS particularly as these mechanisms may relate to Alzheimer's disease (AD) and injury to the developing brain.

Mean distance: 14.48 (cluster 31)
Cross-listing: Alzheimer's Tree

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Snider BJ, Holtzman DM. (2021) Effects of COVID-19 on preclinical and clinical research in neurology: Examples from research on neurodegeneration and Alzheimer's disease. Neuron
Wang H, Kulas JA, Wang C, et al. (2021) Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol. Proceedings of the National Academy of Sciences of the United States of America. 118
Chen X, Sun G, Tian E, et al. (2021) Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2101462
McDade E, Llibre-Guerra JJ, Holtzman DM, et al. (2021) The informed road map to prevention of Alzheimer Disease: A call to arms. Molecular Neurodegeneration. 16: 49
Lemere CA, Head E, Holtzman DM. (2021) APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All. Jama Neurology
Shi Y, Andhey PS, Ising C, et al. (2021) Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms. Neuron
Lall D, Lorenzini I, Mota TA, et al. (2021) C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Neuron
Gratuze M, Chen Y, Parhizkar S, et al. (2021) Activated microglia mitigate Aβ-associated tau seeding and spreading. The Journal of Experimental Medicine. 218
Butt OH, Meeker KL, Wisch JK, et al. (2021) Network dysfunction in cognitively normal APOE ε4 carriers is related to subclinical tau. Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Knopman DS, Amieva H, Petersen RC, et al. (2021) Alzheimer disease. Nature Reviews. Disease Primers. 7: 33
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