César Milstein
Affiliations: | Molecular Biology | MRC Laboratory of Molecular Biology, Cambridge, England, United Kingdom |
Area:
ImmunologyWebsite:
http://www.nobelprize.org/nobel_prizes/medicine/laureates/1984/milstein.htmlGoogle:
"César Milstein"Bio:
(1927 - 2002)
http://www.nasonline.org/member-directory/deceased-members/45964.html
https://www.aai.org/About/History/Notable_Members/Nobel/Milstein_Cesar.html
The Nobel Prize in Physiology or Medicine 1984 was awarded jointly to Niels K. Jerne, Georges J.F. Köhler and César Milstein for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies
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Mean distance: 16.15 (cluster 11) | S | N | B | C | P |
Cross-listing: ImmunoTree
Parents
Sign in to add mentor| Andrés O.M. Stoppani | grad student | 1957 | School of Medicine, University of Buenos Aires, Argentina |
| Malcolm Dixon | grad student | 1960 | Cambridge |
Children
Sign in to add trainee| Nicholas J. Cowan | grad student | MRC-LMB | |
| Chack Yung Yu | grad student | (Neurotree) | |
| Jisnuson Svasti | grad student | 1972 | MRC-LMB |
| Blas Frangione | post-doc | Cambridge (Neurotree) | |
| Georges J.F. Köhler | post-doc | 1974-1976 | MRC-LMB |
| Timothy A. Springer | post-doc | 1976-1977 | MRC-LMB |
| Yair Argon | post-doc | 1984 | Cambridge |
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Publications
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| Milstein C, Galfre G, Secher DS, et al. (2008) Monoclonal Antibodies and Cell Surface Antigens Human Genetics: Possibilities and Realities. 251-281 |
| Rada C, Jarvis JM, Milstein C. (2002) AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization. Proceedings of the National Academy of Sciences of the United States of America. 99: 7003-8 |
| Rada C, Milstein C. (2001) The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. The Embo Journal. 20: 4570-6 |
| Sale JE, Bemark M, Williams GT, et al. (2001) In vivo and in vitro studies of immunoglobulin gene somatic hypermutation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 356: 21-8 |
| Neuberger MS, Ehrenstein MR, Rada C, et al. (2000) Memory in the B-cell compartment: antibody affinity maturation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 355: 357-60 |
| Milstein C. (1999) The hybridoma revolution: an offshoot of basic research. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 21: 966-73 |
| Goyenechea B, Milstein C. (1996) Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation. Proceedings of the National Academy of Sciences of the United States of America. 93: 13979-84 |
| Milstein C, Neuberger MS. (1996) Maturation of the immune response. Advances in Protein Chemistry. 49: 451-85 |
| Aoufouchi S, Yélamos J, Milstein C. (1996) Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis. Cell. 85: 415-22 |
| Chui YL, Lozano F, Jarvis JM, et al. (1995) A reporter gene to analyse the hypermutation of immunoglobulin genes. Journal of Molecular Biology. 249: 555-63 |