Edgar F. da Cruz e Silva, PhD

Cell Biology University of Aveiro, Aveiro, Aveiro, Portugal 
"Edgar da Cruz e Silva"



Edgar Da Cruz E Silva (1958-2010)
4 March, 2010
It is with great sadness that we report the death of Edgar da Cruz e Silva on March 2nd 2010 after a long battle against cancer. Edgar, who worked in the Protein Phosphorylation Group from 1983-1988, just before it became the MRC Protein Phosphorylation Unit, was Tricia Cohen's first Ph.D. student. He was the first person to carry out cDNA cloning using oligonucleotide screening at the University of Dundee, which he exploited to determine the sequence of the catalytic subunit of phosphorylase kinase. The cDNA libraries that he made were also used to isolate the first clones of protein phosphatase 1 and, with his wife Odete (also a Ph.D. student in Tricia's group), the first clones of protein phosphatase 4. After a year as a postdoc in Tricia’s lab, Edgar then spent eight years carrying out postdoctoral research on protein phosphatases at the Rockefeller University, New York with Paul Greengard, who received a Nobel Prize in 2000 for his work on dopamine signaling in the brain. Edgar and Odete moved to the University of Aveiro in Portugal in 1996, where they became founder members of the Centre for Cellular Biology. Over the next 14 years Edgar, who was appointed Professor and later the Director of the Centre, did much to build up strength in biology in Aveiro that put it on the scientific map. Tricia and Philip Cohen visited the Department on several occasions and, with Carol MacKintosh, attended the Europhosphatase 2007 conference in Aveiro, which Edgar organised and ran superbly, despite having been diagnosed with cancer a year before it took place. Edgar was a warm and generous person, and a committed and talented scientist, who will be sadly missed by the cell signaling community. The Unit sends its sincerest condolences to Odete and their two children Cristóvão and David.

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Mean distance: 13.66 (cluster 32)
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Rebelo S, da Cruz E Silva EF, da Cruz E Silva OA. (2015) Genetic mutations strengthen functional association of LAP1 with DYT1 dystonia and muscular dystrophy. Mutation Research. Reviews in Mutation Research. 766: 42-7
Martins F, Rebelo S, Santos M, et al. (2015) BRI2 and BRI3 are functionally distinct phosphoproteins. Cellular Signalling
Rebelo S, Santos M, Martins F, et al. (2015) Protein phosphatase 1 is a key player in nuclear events. Cellular Signalling
Silva JV, Yoon S, Domingues S, et al. (2015) Amyloid precursor protein interaction network in human testis: sentinel proteins for male reproduction. Bmc Bioinformatics. 16: 12
Silva JV, Korrodi-Gregório L, Luers G, et al. (2015) Characterisation of several ankyrin repeat protein variant 2, a phosphoprotein phosphatase 1-interacting protein, in testis and spermatozoa. Reproduction, Fertility, and Development
Santos M, Costa P, Martins F, et al. (2015) LAP1 is a crucial protein for the maintenance of the nuclear envelope structure and cell cycle progression. Molecular and Cellular Biochemistry. 399: 143-53
Santos M, Domingues SC, Costa P, et al. (2014) Identification of a novel human LAP1 isoform that is regulated by protein phosphorylation. Plos One. 9: e113732
Domingues SC, Konietzko U, Henriques AG, et al. (2014) RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60. Journal of Alzheimer's Disease : Jad. 42: 1415-33
Henriques AG, Oliveira JM, Gomes B, et al. (2014) Complexing Aβ prevents the cellular anomalies induced by the Peptide alone. Journal of Molecular Neuroscience : Mn. 53: 661-8
Korrodi-Gregório L, Margarida Lopes A, Esteves SL, et al. (2013) An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model. Plos One. 8: e77236
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