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Odete A. Beirão da Cruz e Silva, PhD

Medical Sciences University of Aveiro, Aveiro, Aveiro, Portugal 
Alzheimer's disease, Biomarker Discovery, Molecular Biomedicine, Regenerative Medicine, Biomaterials for Neuroscience

Dr. da Cruz e Silva is presently a Professor at the University of Aveiro, and Director of the Biomedical Sciences in the Health Sciences Department. The PhD research work, which resulted in the cloning of the protein phosphatases, was carried out at the University of Dundee, a Signal Transduction laboratory headed by Prof. P. Cohen. Subsequently research continued in the Neurosciences with Prof. Paul Greengard and Prof. Sam Gandy at the Rockefeller University, before returning to Portugal where Dr. da Cruz e Silva set up her own research group. The main area of scientific activity has been the pursuit of the molecular basis of Alzheimer’s disease (AD) and the underlying signalling mechanisms which may contribute to this pathology. Precise signalling mechanisms contributing to altered intracellular responses such as abnormal APP processing, in particular Abeta production, have been addressed. The long term goal is to identify signal transduction players which can potentially provide novel diagnostic and therapeutic approaches. Consequently several novel APP binding proteins have been identified. Present research interests also address mechanisms affecting Abeta aggregation, which again may provide novel therapeutic strategies. The researcg group has been successful in participating in three European projects with more than 40 European research groups with whom we collaborate.
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Mean distance: 13.66 (cluster 32)
Cross-listing: Alzheimer's Tree


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Marcio G. Oliveira research assistant University of Aveiro
Joana Oliveira grad student 2015- University of Aveiro
Steven Alves grad student 2018- University of Aveiro
Maria Cachide grad student 2018- University of Aveiro
André Nabais grad student 2018- University of Aveiro
Sandra Vieira grad student 2003-2006 University of Aveiro
Sandra Rebelo grad student 2004-2008 University of Aveiro
Ana Gabriela Henriques grad student 2004-2009 University of Aveiro
Sofia Caçoilo Corticeiro grad student 2009-2012 University of Aveiro
Sara Santos Domingues grad student 2009-2012 University of Aveiro
Sara Esteves grad student 2009-2012 University of Aveiro
Luís Gregório Korrodi grad student 2010-2012 University of Aveiro
Mariana Santos grad student 2010-2014 University of Aveiro
Roberto Dias grad student 2013-2017 University of Aveiro
Filipa Martins grad student 2013-2017 University of Aveiro
Joana Rocha grad student 2013-2017 University of Aveiro
Ilka Martins Rosa grad student 2014-2018 University of Aveiro
Diogo Trigo post-doc 2018- University of Aveiro
Maria Elena C. post-doc 1999-2002 University of Aveiro
Ildete Ferreira post-doc 2003-2004 University of Aveiro
Ana Paula Vintém post-doc 2003-2005 University of Aveiro
Filipa Baptista post-doc 2012-2013 University of Aveiro
Marouane Hachicha post-doc 2013-2014 University of Aveiro
Ana Roque post-doc 2013-2015 University of Aveiro
Dania Teixeira post-doc 2013-2015 University of Aveiro
Renata Tavares post-doc 2014-2015 University of Aveiro
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Serrano JB, Martins F, Sousa JC, et al. (2017) Descriptive Analysis of LAP1 Distribution and That of Associated Proteins throughout Spermatogenesis. Membranes. 7
Domingues C, da Cruz E Silva OA, Henriques AG. (2017) Impact of Cytokines and Chemokines on Alzheimer's Disease Neuropathological Hallmarks. Current Alzheimer Research
Martins F, Serrano JB, Müller T, et al. (2017) BRI2 Processing and its Neuritogenic Role Are Modulated by Protein Phosphatase 1 Complexing. Journal of Cellular Biochemistry
Serrano JB, da Cruz E Silva OA, Rebelo S. (2016) Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features. Membranes. 6
Rebelo S, da Cruz E Silva EF, da Cruz E Silva OA. (2015) Genetic mutations strengthen functional association of LAP1 with DYT1 dystonia and muscular dystrophy. Mutation Research. Reviews in Mutation Research. 766: 42-7
Martins F, Rebelo S, Santos M, et al. (2015) BRI2 and BRI3 are functionally distinct phosphoproteins. Cellular Signalling
Rebelo S, Santos M, Martins F, et al. (2015) Protein phosphatase 1 is a key player in nuclear events. Cellular Signalling
da Rocha JF, da Cruz E Silva OA, Vieira SI. (2015) Analysis of the amyloid precursor protein role in neuritogenesis reveals a biphasic SH-SY5Y neuronal cell differentiation model. Journal of Neurochemistry. 134: 288-301
Silva JV, Yoon S, Domingues S, et al. (2015) Amyloid precursor protein interaction network in human testis: sentinel proteins for male reproduction. Bmc Bioinformatics. 16: 12
Oliveira JM, Henriques AG, Martins F, et al. (2015) Amyloid-β Modulates Both AβPP and Tau Phosphorylation. Journal of Alzheimer's Disease : Jad. 45: 495-507
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