Derek A. Drechsel, Ph.D.
Affiliations: | 2010 | University of Colorado Anschutz Medical Campus, Denver, Aurora, CO |
Area:
Toxicology, Neuroscience BiologyGoogle:
"Derek Drechsel"Mean distance: 26716.5
Parents
Sign in to add mentor| Manisha Patel | grad student | 2010 | University of Colorado, Denver | |
| (Redox mechanisms of paraquat neurotoxicity: Implications for Parkinson's disease.) | ||||
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Publications
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| Chang CH, Drechsel DA, Kitson RR, et al. (2014) 19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity. Molecular Pharmacology. 85: 849-57 |
| Chang C, Drechsel DA, Kitson RRA, et al. (2014) Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity Cancer Research. 74: 1788-1788 |
| Drechsel DA, Estévez AG, Barbeito L, et al. (2012) Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS. Neurotoxicity Research. 22: 251-64 |
| Durazo SA, Kadam RS, Drechsel D, et al. (2011) Brain mitochondrial drug delivery: influence of drug physicochemical properties. Pharmaceutical Research. 28: 2833-47 |
| Cantu D, Fulton RE, Drechsel DA, et al. (2011) Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H₂O₂. Journal of Neurochemistry. 118: 79-92 |
| Drechsel DA, Patel M. (2010) Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system. The Journal of Biological Chemistry. 285: 27850-8 |
| Cantu D, Fulton R, Drechsel D, et al. (2010) Mitochondrial Aconitase Knockdown Decreases Cellular Metabolism and Prevents Paraquat-dependent Dopaminergic Neuronal Death Free Radical Biology and Medicine. 49: S154 |
| Chick WS, Drechsel DA, Hammond W, et al. (2009) Transmission of mutant phenotypes from ES cells to adult mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 20: 734-40 |
| Drechsel DA, Patel M. (2009) Differential contribution of the mitochondrial respiratory chain complexes to reactive oxygen species production by redox cycling agents implicated in parkinsonism. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 427-34 |
| Drechsel DA, Patel M. (2009) Chapter 21 Paraquat-induced production of reactive oxygen species in brain mitochondria. Methods in Enzymology. 456: 381-93 |