Mark A. Lemmon

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Medical Biophysics, Molecular Biology, Biochemistry
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Children

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Courtney M. Smith grad student 2015- Yale
Mitchell B. Berger grad student 2004 Penn
Jong W. Yu grad student 2004 Penn
Mark A. Baumeister grad student 2005 Penn
Kelley A. Bethoney grad student 2008 Penn
Daryl E. Klein grad student 2008 Penn
Katarina Moravcevic grad student 2010 Penn
Scott C. Bresler grad student 2011 Penn
Fumin Shi grad student 2012 Penn
Neo Wu grad student 2009-2015
Joshua B. Sheetz grad student 2016-2022 Yale
Chun Hu grad student 2017-2022 Yale (Neurotree)
Krishna C. Mudumbi post-doc 2018- Yale (Neurotree)

Collaborators

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David Cowburn collaborator
David J. Riese collaborator Yale
BETA: Related publications

Publications

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Mudumbi KC, Burns EA, Schodt DJ, et al. (2023) Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes. Cell Reports. 43: 113603
Chongsaritsinsuk J, Steigmeyer AD, Mahoney KE, et al. (2023) Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE. Nature Communications. 14: 6169
Mühlenbeck H, Tsutsui Y, Lemmon MA, et al. (2023) Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling. Biorxiv : the Preprint Server For Biology
Berko ER, Witek GM, Matkar S, et al. (2023) Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma. Nature Communications. 14: 2601
Mudumbi KC, Burns EA, Schodt DJ, et al. (2023) Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes. Biorxiv : the Preprint Server For Biology
van Alderwerelt van Rosenburgh IK, Lu DM, Grant MJ, et al. (2022) Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. Nature Communications. 13: 6791
Sheetz JB, Lemmon MA. (2022) Looking lively: emerging principles of pseudokinase signaling. Trends in Biochemical Sciences
Sheetz JB, Lemmon MA, Tsutsui Y. (2022) Dynamics of protein kinases and pseudokinases by HDX-MS. Methods in Enzymology. 667: 303-338
Hu C, Leche CA, Kiyatkin A, et al. (2022) Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature. 602: 518-522
Li T, Stayrook SE, Tsutsui Y, et al. (2021) Structural basis for ligand reception by anaplastic lymphoma kinase. Nature. 600: 148-152
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