Kimberly A. Scearce-Levie

Genentech, Inc., San Francisco, CA, United States 
behavioral neuroscience, neurodegeneration
"Kimberly Scearce-Levie"
Mean distance: 13.56 (cluster 6)


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René Hen grad student 1993-2002 Columbia
 (Serotonin 1B receptor knockout mice as an animal model of vulnerability to drugs of abuse.)
Lennart Mucke post-doc 2002-2007 Gladstone Institute
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Xia D, Lianoglou S, Sandmann T, et al. (2022) Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia. Molecular Neurodegeneration. 17: 41
Ayalon G, Lee SH, Adolfsson O, et al. (2021) Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Science Translational Medicine. 13
Scearce-Levie K, Sanchez PE, Lewcock JW. (2020) Leveraging preclinical models for the development of Alzheimer disease therapeutics. Nature Reviews. Drug Discovery. 19: 447-462
Hanson JE, Ma K, Elstrott J, et al. (2020) GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models. Cell Reports. 30: 381-396.e4
Dominguez SL, Hegde GV, Hanson JE, et al. (2018) Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice. Scientific Reports. 8: 8239
Le Pichon CE, Meilandt WJ, Dominguez S, et al. (2017) Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Science Translational Medicine. 9
Wong K, Noubade R, Manzanillo P, et al. (2017) Mice deficient in NRROS show abnormal microglial development and neurological disorders. Nature Immunology
Weber M, Wu T, Meilandt WJ, et al. (2017) BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats. Scientific Reports. 7: 44249
Villemure E, Volgraf M, Jiang Y, et al. (2017) GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. Acs Medicinal Chemistry Letters. 8: 84-89
Ertürk A, Mentz S, Stout EE, et al. (2016) Interfering with the Chronic Immune Response Rescues Chronic Degeneration After Traumatic Brain Injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9962-75
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