Kimberly A. Scearce-Levie

Affiliations: 
Genentech, San Francisco, CA, United States 
Area:
behavioral neuroscience, neurodegeneration
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"Kimberly Scearce-Levie"
Mean distance: 13.56 (cluster 6)
 
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Parents

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René Hen grad student 1993-2002 Columbia
 (Serotonin 1B receptor knockout mice as an animal model of vulnerability to drugs of abuse.)
Lennart Mucke post-doc 2002-2007 Gladstone Institute
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Publications

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Lo SC, Scearce-Levie K, Sheng M. (2016) Characterization of Social Behaviors in caspase-3 deficient mice. Scientific Reports. 6: 18335
Weber M, Wu T, Hanson JE, et al. (2015) Cognitive Deficits, Changes in Synaptic Function, and Brain Pathology in a Mouse Model of Normal Aging(1,2,3). Eneuro. 2
Patel S, Harris SF, Gibbons P, et al. (2015) Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). Journal of Medicinal Chemistry
Lo SC, Wang Y, Weber M, et al. (2015) Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2118-32
Yamazaki M, Le Pichon CE, Jackson AC, et al. (2015) Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior. Proceedings of the National Academy of Sciences of the United States of America. 112: E371-9
Patel S, Cohen F, Dean BJ, et al. (2015) Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. Journal of Medicinal Chemistry. 58: 401-18
Thomas AA, Hunt KW, Newhouse B, et al. (2014) 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors. Journal of Medicinal Chemistry. 57: 10112-29
Yu YJ, Atwal JK, Zhang Y, et al. (2014) Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154
Hanson JE, Meilandt WJ, Gogineni A, et al. (2014) Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8277-88
Kallop DY, Meilandt WJ, Gogineni A, et al. (2014) A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6425-37
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