Kimberly A. Scearce-Levie

Genentech, Inc., San Francisco, CA, United States 
behavioral neuroscience, neurodegeneration
"Kimberly Scearce-Levie"
Mean distance: 13.56 (cluster 6)


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René Hen grad student 1993-2002 Columbia
 (Serotonin 1B receptor knockout mice as an animal model of vulnerability to drugs of abuse.)
Lennart Mucke post-doc 2002-2007 Gladstone Institute
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Bhalla A, Ravi R, Fang M, et al. (2020) Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients. International Journal of Molecular Sciences. 21
Scearce-Levie K, Sanchez PE, Lewcock JW. (2020) Leveraging preclinical models for the development of Alzheimer disease therapeutics. Nature Reviews. Drug Discovery. 19: 447-462
Hanson JE, Ma K, Elstrott J, et al. (2020) GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models. Cell Reports. 30: 381-396.e4
Hodgson R, Kennedy BK, Masliah E, et al. (2019) AGING: THERAPEUTICS FOR A HEALTHY FUTURE. Neuroscience and Biobehavioral Reviews
Dominguez SL, Hegde GV, Hanson JE, et al. (2018) Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice. Scientific Reports. 8: 8239
Bumbaca Yadav D, Maloney JA, Wildsmith KR, et al. (2017) Widespread brain distribution and activity following anti-BACE1 intracerebroventricular infusion in nonhuman primates. British Journal of Pharmacology
Le Pichon CE, Meilandt WJ, Dominguez S, et al. (2017) Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Science Translational Medicine. 9
Wong K, Noubade R, Manzanillo P, et al. (2017) Mice deficient in NRROS show abnormal microglial development and neurological disorders. Nature Immunology
Weber M, Wu T, Meilandt WJ, et al. (2017) BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats. Scientific Reports. 7: 44249
Villemure E, Volgraf M, Jiang Y, et al. (2017) GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. Acs Medicinal Chemistry Letters. 8: 84-89
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