James E. Darnell

Rockefeller University, New York, NY, United States 
STATs, development
"James Darnell"

Discovered hnRNA.

Mean distance: 13.78 (cluster 11)


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Daniel Lew grad student Rockefeller (Cell Biology Tree)
Ke Shuai grad student (Chemistry Tree)
Jonathan Warner grad student MIT
Jeffrey M. Friedman grad student 1986 Rockefeller
Aurel Betz grad student 2001 Rockefeller
Ronald M. Evans post-doc Rockefeller
Uno Lindberg post-doc Albert Einstein
Klaus Scherrer post-doc MIT
Ruy Soeiro post-doc Albert Einstein
Hermona Soreq post-doc Rockefeller
Michael C. Wilson post-doc University of New Mexico, Albuquerque
David Baltimore post-doc 1963-1964 MIT (Chemistry Tree)
Xin-Yuan Fu post-doc 1988-1991 Rockefeller
Sheldon Penman research scientist MIT


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David Cowburn collaborator (Chemistry Tree)
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Mertens C, Haripal B, Klinge S, et al. (2015) Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity. Proceedings of the National Academy of Sciences of the United States of America
Darnell JE. (2013) Joys and surprises of a career studying eukaryotic gene expression. The Journal of Biological Chemistry. 288: 12957-66
Darnell JE. (2013) Reflections on the history of pre-mRNA processing and highlights of current knowledge: a unified picture. Rna (New York, N.Y.). 19: 443-60
Stark GR, Darnell JE. (2012) The JAK-STAT pathway at twenty. Immunity. 36: 503-14
Schindler C, Shuai K, Prezioso VR, et al. (2011) Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813. Journal of Immunology (Baltimore, Md. : 1950). 187: 5489-94
Darnell JE. (2010) STAT3, HIF-1, glucose addiction and Warburg effect. Aging. 2: 890-1
Ahmed ST, Darnell JE. (2009) Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells. Biochemical and Biophysical Research Communications. 378: 821-5
Betz A, Ryoo HD, Steller H, et al. (2008) STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 13805-10
Darnell JE. (2007) Interferon research: impact on understanding transcriptional control. Current Topics in Microbiology and Immunology. 316: 155-63
Ginsberg M, Czeko E, Müller P, et al. (2007) Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos. Molecular and Cellular Biology. 27: 6300-8
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