Shinu John, Ph.D.

Affiliations: 
2007 Biochemistry State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Biochemistry, Immunology
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Parents

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Lee Ann Garrett-Sinha grad student 2007 SUNY Buffalo
 (Increased plasma cell differentiation, hyper-responsiveness to TLR9, and loss of peripheral B cell tolerance in mice lacking the transcription factor Ets -1.)
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Publications

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Tilstra JS, John S, Gordon RA, et al. (2020) B cell-intrinsic TLR9 expression is protective in murine lupus. The Journal of Clinical Investigation
John S, Yuzhakov O, Woods A, et al. (2018) Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity. Vaccine
Lindgren G, Ols S, Liang F, et al. (2017) Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells. Frontiers in Immunology. 8: 1539
Roberts AW, Lee BL, Deguine J, et al. (2017) Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells. Immunity
Liang F, Lindgren G, Lin A, et al. (2017) Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques. Molecular Therapy : the Journal of the American Society of Gene Therapy
Xu RH, Wong EB, Rubio D, et al. (2015) Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection. Immunity. 43: 1148-59
Russell L, John S, Cullen J, et al. (2015) Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens. Journal of Immunology (Baltimore, Md. : 1950). 195: 3574-83
Mayeux J, Skaug B, Luo W, et al. (2015) Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels. Journal of Immunology (Baltimore, Md. : 1950)
John S, Russell L, Chin SS, et al. (2014) Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation. Molecular and Cellular Biology. 34: 522-32
John SA, Garrett-Sinha LA. (2009) Blimp1: a conserved transcriptional repressor critical for differentiation of many tissues. Experimental Cell Research. 315: 1077-84
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