Michael A. Holinstat

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmacology, cardiovascular, thrombosis, human, mice, platelets
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Parents

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Asrar Malik grad student 2000-2004 University of Illinois at Chicago, Health Sciences Center
 (RhoA regulation of endothelial monolayer integrity.)
Heidi E. Hamm post-doc 2004-2008 Vanderbilt University Medical School (Chemistry Tree)

Collaborators

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Aditi Das collaborator
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Publications

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Holinstat M. (2021) Controlling the Clot: ANXA7 Regulates Collagen Activation of Platelet Through 12-LOX. Circulation Research. 129: 508-510
Duan X, Perveen R, Dandamudi A, et al. (2021) Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Scientific Reports. 11: 13170
Adili R, Jackson M, Stanger L, et al. (2021) Slounase, a Batroxobin Containing Activated Factor X Effectively Enhances Hemostatic Clot Formation and Reducing Bleeding in Hypocoagulant Conditions in Mice. Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 27: 10760296211018510
Zaslavsky A, Adams M, Cao X, et al. (2021) Antisense oligonucleotides and nucleic acids generate hypersensitive platelets. Thrombosis Research. 200: 64-71
Yamaguchi A, Stanger L, Freedman CJ, et al. (2020) DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway. Journal of Thrombosis and Haemostasis : Jth
Yeung J, Adili R, Stringham EN, et al. (2020) GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force. Proceedings of the National Academy of Sciences of the United States of America
Yeung J, Adili R, Yamaguchi A, et al. (2020) Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner. Blood Advances. 4: 4522-4537
Freedman CJ, Tran A, Tourdot BE, et al. (2020) Biosynthesis of the Maresin Intermediate, 13S,14S-epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and its Regulation through Negative Allosteric Modulators. Biochemistry
Holinstat M. (2019) Resolvin the clot: DVT resolution through RvD4. Blood. 134: 1370-1371
Rost MS, Shestopalov I, Liu Y, et al. (2018) Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood Advances. 2: 3418-3427
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