George J. Yohrling

Johnson and Johnson, Manor, TX, United States 
Neurodegenerative disease
"George Yohrling"
Mean distance: 16.27 (cluster 11)
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Huang Y, Strobel ED, Ho CY, et al. (2010) Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads. Bioorganic & Medicinal Chemistry Letters. 20: 3158-60
Liu Y, Yohrling GJ, Wang Y, et al. (2009) Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons. Epilepsy Research. 83: 66-72
Benn CL, Sun T, Sadri-Vakili G, et al. (2008) Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10720-33
Yohrling GJ, Felsenstein KM, Conway KA, et al. (2007) A comparative analysis of brain and plasma Abeta levels in eight common non-transgenic mouse strains: validation of a specific immunoassay for total rodent Abeta. Current Alzheimer Research. 4: 297-303
Sadri-Vakili G, Bouzou B, Benn CL, et al. (2007) Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models. Human Molecular Genetics. 16: 1293-306
Sadri-Vakili G, Menon AS, Farrell LA, et al. (2006) Huntingtin inclusions do not down-regulate specific genes in the R6/2 Huntington's disease mouse. The European Journal of Neuroscience. 23: 3171-5
Chen-Plotkin AS, Sadri-Vakili G, Yohrling GJ, et al. (2006) Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease. Neurobiology of Disease. 22: 233-41
Braveman MW, Chen-Plotkin AS, Yohrling GJ, et al. (2004) Chromatin immunoprecipitation technique for study of transcriptional dysregulation in intact mouse brain. Methods in Molecular Biology (Clifton, N.J.). 277: 261-76
Yohrling GJ, Jiang GC, DeJohn MM, et al. (2003) Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology. Brain Research. Molecular Brain Research. 119: 28-36
Yohrling GJ, Farrell LA, Hollenberg AN, et al. (2003) Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation. Molecular and Cellular Neurosciences. 23: 28-38
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