Mark Steven Kleven, Ph.D.
Affiliations: | Pharmacology | University of Minnesota, Twin Cities, Minneapolis, MN |
Area:
PsychopharmacologyGoogle:
"Mark S. Kleven"Bio:
Mark S. Kleven is currently Vice President of Product Development, Biousian Biosystems, Inc. Dr. Kleven received his Ph.D. in Pharmacology from the University of Minnesota and had post-doctoral training in neuropsychopharmacology in the Departments of Psychiatry and Pharmacology and Physiological Sciences at the University of Chicago. Before moving to the pharmaceutical industry he served on the Faculty at the University of Chicago as a Research Assistant Professor. Dr. Kleven was previously Vice President, Scientific Operations at Yaupon Therapeutics, Inc. and Head of Behavioral Pharmacology at the Centre de Recherche Pierre Fabre, CASTRES, France. During the twelve years at Laboratoire Fabre he was involved in pivotal studies identifying six drug development candidates for CNS diseases. While at Yaupon Therapeutics he directed both non-clinical and clinical stages of drug development in the areas of neuropathic pain, drug
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Publications
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| Newman-Tancredi A, Depoortère R, Carilla-Durand E, et al. (2017) NLX-112, a highly selective 5-HT receptor agonist: Effects on body temperature and plasma corticosterone levels in rats. Pharmacology, Biochemistry, and Behavior. 165: 56-62 |
| Kleven MS, Assié MB, Koek W. (1997) Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats. The Journal of Pharmacology and Experimental Therapeutics. 282: 747-59 |
| Kleven MS, Sparber SB. (1989) Modification of quasi-morphine withdrawal with serotonin agonists and antagonists: evidence for a role of serotonin in the expression of opiate withdrawal. Psychopharmacology. 98: 231-5 |
| Kleven MS, Woolverton WL, Seiden LS. (1989) Evidence that both intragastric and subcutaneous administration of methylenedioxymethylamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys. Brain Research. 488: 121-5 |
| Kleven MS, Schuster CR, Seiden LS. (1988) Effect of depletion of brain serotonin by repeated fenfluramine on neurochemical and anorectic effects of acute fenfluramine. The Journal of Pharmacology and Experimental Therapeutics. 246: 822-8 |
| Kleven MS, Sparber SB. (1987) Attenuation of isobutylmethylxanthine-induced suppression of operant behavior by pretreatment of rats with clonidine. Pharmacology, Biochemistry, and Behavior. 28: 235-41 |
| Messing RB, Kleven MS, Sparber SB. (1986) Delaying reinforcement in an autoshaping task generates adjunctive and superstitious behaviors. Behavioural Processes. 13: 327-38 |
| Sparber SB, Dwoskin LP, Kleven MS. (1986) Studies on the specificity of neurochemical and behavioral effects of LSD-25. Pharmacology, Biochemistry, and Behavior. 24: 341-5 |
| Klauenberg BJ, Kleven MS, Sparber SB. (1985) Behaviorally equivalent stressors differentially modify the monoamine altering property of d-amphetamine. Pharmacology, Biochemistry, and Behavior. 23: 417-23 |
| Kleven MS, Dwoskin LP, Sparber SB. (1983) Pharmacological evidence for the existence of multiple functional pools of brain serotonin: analysis of brain perfusate from conscious rats. Journal of Neurochemistry. 41: 1143-9 |