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Richard F. Borch, M.D., Ph.D.

Affiliations: 
Purdue University, West Lafayette, IN, United States 
Area:
Anticancer Drugs: Design, Synthesis, and Mechanisms of Action
Website:
http://www.mcmp.purdue.edu/faculty/?uid=rickb
Google:
"Richard F. Borch"
Bio:

http://www.chem.umn.edu/alumni/IndFacPages/Borch.html

Mean distance: 7.49
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Parents

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Gilbert Stork grad student 1965 Columbia
 (A synthesis of cis-jasmone. An approach to the synthesis of vitamin B12)

Children

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Caren L Freel Meyers grad student
Thomas J. Montine grad student Rochester (Neurotree)
Stan Raucher grad student
Peter Dedon grad student 1982- UMN
Liping H. Pettus grad student 1993-1995 University of Rochester Medical Center
Hugo Garrido Hernandez grad student 2001 Purdue
Marcy Hernick grad student 2002 Purdue
Melissa D. Zolodz grad student 2003 Purdue
Rong Huang grad student 2001-2006 Purdue
Rodney Nyland grad student 2003-2007
Christine Marian grad student 2013 Purdue

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Publications

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Huang R, Oh H, Arrendale A, et al. (2013) Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK. Biochemical Pharmacology. 86: 597-611
Arrendale A, Kim K, Choi JY, et al. (2012) Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity. Chemistry & Biology. 19: 764-71
Marian C, Huang R, Borch RF. (2011) Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold. Tetrahedron. 67: 10216-10221
Kelley MR, Luo M, Reed A, et al. (2011) Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1. Antioxidants & Redox Signaling. 14: 1387-401
Arrendale AA, Huang R, Geahlen R, et al. (2011) Abstract B184: Design, synthesis, and evaluation of novel mitotic centromere-associated kinesin (MCAK) inhibitors. Molecular Cancer Therapeutics. 10
Arrendale AA, Kim K, Geahlen R, et al. (2011) Abstract A124: Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity. Molecular Cancer Therapeutics. 10
Nyland RL, Luo M, Kelley MR, et al. (2010) Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1). Journal of Medicinal Chemistry. 53: 1200-10
Luo M, Delaplane S, Jiang A, et al. (2008) Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1. Antioxidants & Redox Signaling. 10: 1853-67
Wu W, Borch RF. (2006) Synthesis and biological activity of N-2,3-dihydroxypropyl-N-4-chlorobutyl nucleoside phosphoramidate prodrugs. Molecular Pharmaceutics. 3: 451-6
Dilworth JT, Kraniak JM, Wojtkowiak JW, et al. (2006) Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1. Biochemical Pharmacology. 72: 1485-92
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