Yasser Heakal, Ph.D.

Affiliations: 
2009 Pennsylvania State University, State College, PA, United States 
Area:
Pharmacology
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"Yasser Heakal"
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Mark Kester grad student 2009 Penn State
 (Identification of novel pharmacological approaches to inhibit neurotensin receptor -1 mitogenic signaling in breast cancer cells.)
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Publications

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Masso-Welch P, Girald Berlingeri S, King-Lyons ND, et al. (2018) LT-IIc, A Bacterial Type II Heat-Labile Enterotoxin, Induces Specific Lethality in Triple Negative Breast Cancer Cells by Modulation of Autophagy and Induction of Apoptosis and Necroptosis. International Journal of Molecular Sciences. 20
Heakal Y, Kester M, Savage S. (2011) Vemurafenib (PLX4032): an orally available inhibitor of mutated BRAF for the treatment of metastatic melanoma. The Annals of Pharmacotherapy. 45: 1399-405
Jiang Y, DiVittore NA, Kaiser JM, et al. (2011) Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer. Cancer Biology & Therapy. 12: 574-85
Heakal Y, Woll MP, Fox T, et al. (2011) Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains. Cancer Biology & Therapy. 12: 427-35
Heakal Y, Kester M. (2009) Nanoliposomal short-chain ceramide inhibits agonist-dependent translocation of neurotensin receptor 1 to structured membrane microdomains in breast cancer cells. Molecular Cancer Research : McR. 7: 724-34
Kester M, Heakal Y, Fox T, et al. (2008) Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells. Nano Letters. 8: 4116-21
Zolnik BS, Stern ST, Kaiser JM, et al. (2008) Rapid distribution of liposomal short-chain ceramide in vitro and in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1709-15
Jiang Y, Kaiser J, Heakal Y, et al. (2007) Growth inhibitory effect of ceramide-incorporated nanoliposomes in human pancreatic cancer cells Journal of Clinical Oncology. 25: 14105-14105
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