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Guy C. Le Breton

Affiliations: 
University of Illinois at Chicago, Health Sciences Center, Chicago, IL 60612, United States 
Area:
Cell Biology, Pharmacology, Neuroscience Biology
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"Guy Le Breton"
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Parents

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Children

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Jeanne M. Manganello grad student 2000 University of Illinois at Chicago, Health Sciences Center
Joseph W. Turek grad student 2002 University of Illinois at Chicago, Health Sciences Center
Samuel C. Blackman grad student 2005 University of Illinois at Chicago, Health Sciences Center
Santosh Ramamurthy grad student 2005 University of Illinois at Chicago, Health Sciences Center
Fadi T. Khasawneh grad student 2007 University of Illinois at Chicago, Health Sciences Center

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Publications

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Srinivasan S, Schiemer J, Zhang X, et al. (2015) Gα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets. The Journal of Biological Chemistry
Gussin HA, Khasawneh FT, Xie A, et al. (2011) Subunit-specific polyclonal antibody targeting human ρ1 GABA(C) receptor. Experimental Eye Research. 93: 59-64
Srinivasan S, Mir F, Huang JS, et al. (2009) The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels. The Journal of Biological Chemistry. 284: 16108-17
Mir F, Le Breton GC. (2008) A novel nuclear signaling pathway for thromboxane A2 receptors in oligodendrocytes: evidence for signaling compartmentalization during differentiation. Molecular and Cellular Biology. 28: 6329-41
Khasawneh FT, Huang JS, Mir F, et al. (2008) Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF(2alpha) with the thromboxane A(2) receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets. Biochemical Pharmacology. 75: 2301-15
Huang JS, Dong L, Kozasa T, et al. (2007) Signaling through G(alpha)13 switch region I is essential for protease-activated receptor 1-mediated human platelet shape change, aggregation, and secretion. The Journal of Biological Chemistry. 282: 10210-22
Ramamurthy S, Mir F, Gould RM, et al. (2006) Characterization of thromboxane A2 receptor signaling in developing rat oligodendrocytes: nuclear receptor localization and stimulation of myelin basic protein expression. Journal of Neuroscience Research. 84: 1402-14
Khasawneh FT, Huang JS, Turek JW, et al. (2006) Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein. The Journal of Biological Chemistry. 281: 26951-65
Huang JS, Dong L, Le Breton GC. (2006) Mass-dependent signaling between G protein coupled receptors. Cellular Signalling. 18: 564-76
Lin X, Ramamurthy SK, Le Breton GC. (2005) Thromboxane A receptor-mediated cell proliferation, survival and gene expression in oligodendrocytes. Journal of Neurochemistry. 93: 257-68
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