John F. Couse, Ph.D.

Affiliations: 
2004 North Carolina State University, Raleigh, NC 
Area:
Toxicology, Obstetrics and Gynecology, Animal Physiology Biology
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Robert C. Smart grad student 2004 NCSU
 (The role of estrogen receptor-alpha and estrogen receptor-beta in the hyperluteinized mouse ovary.)
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Publications

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Davis VL, Newbold RR, Couse JF, et al. (2012) Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol. Reproductive Toxicology (Elmsford, N.Y.). 34: 512-21
Walker VR, Jefferson WN, Couse JF, et al. (2012) Estrogen receptor-α mediates diethylstilbestrol-induced feminization of the seminal vesicle in male mice. Environmental Health Perspectives. 120: 560-5
Allan CM, Couse JF, Simanainen U, et al. (2010) Estradiol induction of spermatogenesis is mediated via an estrogen receptor-{alpha} mechanism involving neuroendocrine activation of follicle-stimulating hormone secretion. Endocrinology. 151: 2800-10
Chen L, Bi J, Nakai M, et al. (2010) Expression of basigin in reproductive tissues of estrogen receptor-{alpha} or -{beta} null mice. Reproduction (Cambridge, England). 139: 1057-66
Rodriguez KF, Couse JF, Jayes FL, et al. (2010) Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}. Endocrinology. 151: 2826-34
Deroo BJ, Rodriguez KF, Couse JF, et al. (2009) Estrogen receptor beta is required for optimal cAMP production in mouse granulosa cells. Molecular Endocrinology (Baltimore, Md.). 23: 955-65
Athirakul K, Bradbury JA, Graves JP, et al. (2008) Increased blood pressure in mice lacking cytochrome P450 2J5. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 4096-108
Taniguchi F, Couse JF, Rodriguez KF, et al. (2007) Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 586-95
Lindzey J, Jayes FL, Yates MM, et al. (2006) The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen receptor-alpha. The Journal of Endocrinology. 191: 309-17
Couse JF, Yates MM, Rodriguez KF, et al. (2006) The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad. Endocrinology. 147: 3666-78
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