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Dennis J. Selkoe, MD

Neurology Harvard Medical School, Boston, MA, United States 
"Dennis Selkoe"
Mean distance: 15.29 (cluster 31)
Cross-listing: Alzheimer's Tree - Neuropathology Tree

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Lagomarsino VN, Pearse RV, Liu L, et al. (2021) Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Neuron
Glajch KE, Moors TE, Chen Y, et al. (2021) Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proceedings of the National Academy of Sciences of the United States of America. 118
Fonseca-Ornelas L, Viennet T, Rovere M, et al. (2021) Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease. Cell Reports. 36: 109333
Liu L, Lauro BM, Wolfe MS, et al. (2021) Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides. The Journal of Biological Chemistry. 100393
Chhatwal JP, Schultz AP, Dang Y, et al. (2020) Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nature Communications. 11: 6024
Ho GPH, Ramalingam N, Imberdis T, et al. (2020) Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity. Movement Disorders : Official Journal of the Movement Disorder Society
Nuber S, Nam AY, Rajsombath MM, et al. (2020) A stearoyl-CoA desaturase inhibitor prevents multiple Parkinson's disease-phenotypes in α-synuclein mice. Annals of Neurology
Lauwers E, Lalli G, Brandner S, et al. (2020) Potential human transmission of amyloid β pathology: surveillance and risks. The Lancet. Neurology. 19: 872-878
Terry-Kantor E, Tripathi A, Imberdis T, et al. (2020) Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor. International Journal of Molecular Sciences. 21
Fanning S, Selkoe D, Dettmer U. (2020) Vesicle trafficking and lipid metabolism in synucleinopathy. Acta Neuropathologica
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