Israel Silman

Affiliations: 
STB Structural Biology Weizmann Institute of Science, Rehovot, Israel 
Area:
Neuroscience Biology, General Biophysics
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"Israel Silman"
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Publications

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Nachon F, Rosenberry TL, Silman I, et al. (2020) A Second Look at the Crystal Structures of Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides. Molecules (Basel, Switzerland). 25
Toker L, Silman I, Zeev-Ben-Mordehai T, et al. (2020) Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers. Chemico-Biological Interactions. 109007
Chandar NB, Efremenko I, Silman I, et al. (2019) Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design. Chemico-Biological Interactions
Novichkova DA, Lushchekina SV, Dym O, et al. (2019) The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability. Chemico-Biological Interactions
Oukoloff K, Coquelle N, Bartolini M, et al. (2019) Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. European Journal of Medicinal Chemistry. 168: 58-77
Leung MR, van Bezouwen LS, Schopfer LM, et al. (2018) Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly. Proceedings of the National Academy of Sciences of the United States of America
Lalut J, Santoni G, Karila D, et al. (2018) Novel multitarget-directed ligands targeting acetylcholinesterase and σ receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase. European Journal of Medicinal Chemistry. 162: 234-248
Santoni G, de Sousa J, De la Mora E, et al. (2018) Structure-based optimization of non-quaternary reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Journal of Medicinal Chemistry
Goldenzweig A, Goldsmith M, Hill SE, et al. (2018) Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Molecular Cell. 70: 380
Zorbaz T, Braïki A, Marakovic N, et al. (2018) Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration. Chemistry (Weinheim An Der Bergstrasse, Germany)
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