De-Ming Chau, Ph.D.
Affiliations: | 2011 | Weill Cornell Medical College, New York, NY, United States |
Area:
Biochemistry, Pharmacology, Neuroscience Biology, OncologyGoogle:
"De-Ming Chau"Mean distance: 42746.4
Parents
Sign in to add mentor| Yue-ming Li | grad student | 2011 | Weill Cornell Medical College | |
| (Biochemical and Pharmacological Study of gamma-Secretase in Alzheimer's Disease and Cancer.) | ||||
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Publications
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| Yusof HH, Lee HC, Seth EA, et al. (2019) Expression Profiling of Notch Signalling Pathway and Gamma-Secretase Activity in the Brain of Ts1Cje Mouse Model of Down Syndrome. Journal of Molecular Neuroscience : Mn |
| Gertsik N, Chau DM, Li YM. (2015) γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase. Acs Chemical Biology. 10: 1925-31 |
| Chau DM, Shum D, Radu C, et al. (2013) A novel high throughput 1536-well notch1 γsecretase AlphaLISA assay Combinatorial Chemistry and High Throughput Screening. 16: 415-424 |
| Chau DM, Crump CJ, Villa JC, et al. (2012) Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase. The Journal of Biological Chemistry. 287: 17288-96 |
| Crump CJ, am Ende CW, Ballard TE, et al. (2012) Development of clickable active site-directed photoaffinity probes for γ-secretase. Bioorganic & Medicinal Chemistry Letters. 22: 2997-3000 |
| Crump CJ, Fish BA, Castro SV, et al. (2011) Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1. Acs Chemical Neuroscience. 2: 705-710 |
| Shelton CC, Zhu L, Chau D, et al. (2009) Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 106: 20228-33 |
| Gómez-Nuñez M, Haro KJ, Dao T, et al. (2008) Non-natural and photo-reactive amino acids as biochemical probes of immune function. Plos One. 3: e3938 |
| Haro KJ, Gomez-Nunez M, Dao T, et al. (2007) Photo-Reactive and Non-Natural Amino Acid Epitopes of Human WT1 Enhance Immunogenicity and Allow Kinetic Study of Antigen Processing. Blood. 110: 2311-2311 |